Cold Spring Harbor Laboratory

Oncology & Cancer

Exploiting cancer's sweet tooth to develop a treatment

Inositol is a sugar required for cells to survive. Most cells either get it from the bloodstream or make it themselves. Since there is plenty of inositol available, some cancer cells decide to stop making it. Cold Spring ...

Neuroscience

Mammalian motivation circuits: Maybe they're born with it

Are we born to fear punishment or crave rewards? Or do those capacities evolve with experience? Cold Spring Harbor Laboratory (CSHL) Professor Bo Li and his lab found that mice have pre-programmed circuits that process "positive" ...

Neuroscience

Comparative cellular analysis of motor cortex across species

In 2013, the U.S. government began investing $100 million to decipher how the human brain works in a collaborative project called the BRAIN Initiative. Cold Spring Harbor Laboratory (CSHL) and other researchers built tools ...

Oncology & Cancer

How high-fat diets allow cancer cells to go unnoticed

A high-fat diet increases the incidence of colorectal cancer. Cold Spring Harbor Laboratory Fellow Semir Beyaz and collaborators from Harvard Medical School and Massachusetts Institute of Technology have discovered that ...

Oncology & Cancer

Preventing lung cancer's unwelcome return

When a doctor gives a patient antibiotics for a bacterial infection, they usually require them to finish the entire treatment, even when symptoms go away. This is to ensure the drugs kill off any remaining bacteria. Cold ...

Oncology & Cancer

How pancreatic cancer cells dodge drug treatments

Cancer cells can become resistant to treatments through adaptation, making them notoriously tricky to defeat and highly lethal. Cold Spring Harbor Laboratory (CSHL) Cancer Center Director David Tuveson and his team investigated ...

Neuroscience

Diagramming the brain with colorful connections

There are billions of neurons in the human brain, and scientists want to know how they are connected. Cold Spring Harbor Laboratory (CSHL) Alle Davis and Maxine Harrison Professor of Neurosciences Anthony Zador, and colleagues ...

Neuroscience

Reversing a genetic cause of poor stress responses in mice

Everyone faces stress occasionally, whether in school, at work, or during a global pandemic. However, some cannot cope as well as others. In a few cases, the cause is genetic. In humans, mutations in the OPHN1 gene cause ...

Medical research

Regulatory RNAs promote breast cancer metastasis

Cold Spring Harbor Laboratory (CSHL) scientists have discovered a gene-regulating snippet of RNA that may contribute to the spread of many breast cancers. In animal experiments, the researchers could reduce the growth of ...

Neuroscience

How does the brain process fear?

When a frightful creature startles you, your brain may activate its fear-processing circuitry, sending your heart racing to help you escape the threat. It's also the job of the brain's fear-processing circuits to help you ...

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