Journal of Clinical Investigation
The Journal of Clinical Investigation is a monthly open access biomedical scientific journal, with a 2010 impact factor of 14.152. It was established in 1924. The editorial board is unusual in that its members are located chiefly at a single academic medical center and are predominantly members of the American Society for Clinical Investigation. Its leadership changes every five years: As of March 2007, it is located at the University of Pennsylvania and the current editor-in-chief is Laurence A. Turka (Harvard University). From March 2002 to March 2007, the board was located at Columbia University, with Andrew Marks as editor-in-chief.
Gene replacement in pigs ameliorates cystic fibrosis-associated intestinal obstruction
Cystic fibrosis (CF) is caused by mutations in CFTR and is characterized by dysfunction of the lungs, liver, pancreas, and intestines. Approximately 15% of babies with CF are born with an obstruction of the small intestine ...
Diseases, Conditions, Syndromes
May 08, 2013 |
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Alzheimer's disease is associated with removal of the synaptic protein ADAM10
Alzheimer's disease is characterized by the accumulation of neurotoxic β-amyloid peptide (A-beta). ADAM10, a protein that resides in the neural synapses, has previously been shown to prevent the formation of A-beta.
Alzheimer's disease & dementia
May 08, 2013 |
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HPV leaves its mark in oropharyngeal squamous cell carcinoma
Oropharyngeal squamous cell carcinoma (OPSCC) is a form of cancer that affects the cells lining the middle part of the throat, including the soft palate, the base of the tongue, the tonsils, and the pharynx.
Cancer
May 01, 2013 |
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Searching for therapeutic synergy in primary effusion lymphoma
Primary effusion lymphoma (PEL) is a rare, fatal form of aggressive B-cell lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV). The disease most commonly occurs in immunocompromised patients, such as those with ...
Cancer
May 01, 2013 |
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No rebirth for insulin secreting pancreatic beta cells
Pancreatic beta cells store and release insulin, the hormone responsible for stimulating cells to convert glucose to energy. The number of beta cells in the pancreas increases in response to greater demand for insulin or ...
Medical research
Apr 24, 2013 |
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A potential biomarker for pregnancy-associated heart disease?
Peripartum cardiomyopathy (PPCM) is a deterioration in cardiac function that occurs in pregnant women during the last month or in the months following their pregnancy. This disorder can occur in women with no prior history ...
Diseases, Conditions, Syndromes
Apr 24, 2013 |
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Resistance is futile: Researchers identify gene that mediates cisplatin resistance in ovarian cancer
Platinum compounds, such as cisplatin and carboplatin, induce DNA cross-linking, prohibiting DNA synthesis and repair in rapidly dividing cells. They are first line therapeutics in the treatment of many solid tumors, but ...
Cancer
Apr 15, 2013 |
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Researchers untangle molecular pathology of giant axonal neuropathy
Giant axonal neuropathy (GAN) is a rare genetic disorder that causes central and peripheral nervous system dysfunction. GAN is known to be caused by mutations in the gigaxonin gene and is characterized by tangling and aggregation ...
Neuroscience
Apr 15, 2013 |
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Protecting against aging at the molecular level
Research from Western University and Lawson Health Research Institute sheds new light on a gene called ATRX and its function in the brain and pituitary. Children born with ATRX syndrome have cognitive defects and developmental ...
Medical research
Apr 08, 2013 |
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Researchers identify transcription factors that regulate retinal vascularization
The retina is a highly vascularized tissue, but too much or too little vascularization can lead to visual impairment and diseases such as familial exudative vitreoretinopathy or macular degeneration. In this issue of the ...
Medical research
Apr 08, 2013 |
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Alternative fuel for your brain
Tight control of blood glucose levels is critical to mitigating the long-term complications of diabetes; however, the intensive insulin therapy required for this control is frequently accompanied by recurrent episodes of ...
Medical research
Apr 01, 2013 |
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Promoting muscle regeneration in a mouse model of muscular dystrophy
Duchenne muscular dystrophy (DMD) is a degenerative skeletal muscle disease caused by mutations in the protein dystrophin. Dystrophin functions to protect muscle cells from injury and loss of functional dystrophin results ...
Medical research
Apr 01, 2013 |
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Exploring the cause of sudden unexplained death in epilepsy
Dravet syndrome (DS) is a form of infantile-onset, treatment-resistant epilepsy that is caused by a mutation in the gene encoding a voltage-gated sodium channel, SCN1A. DS patients have a 30-fold increased risk of dying from ...
Medical research
Mar 25, 2013 |
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Lymphatic vasculature: A cholesterol removal system
Reverse cholesterol transport is a process in which accumulated cholesterol is removed from tissues, including the artery wall, and transported back to the liver for excretion. Little is known about how cholesterol is removed ...
Medical research
Mar 25, 2013 |
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Sorting out fertility after childhood cancer
As success rates in treating childhood cancers have improved, greater emphasis is being placed on quality of life issues following successful treatment. Many cancer treatments can lead to infertility, but there are few methods ...
Cancer
Mar 15, 2013 |
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