Journal of Clinical Investigation

A potential biomarker for pregnancy-associated heart disease?

Peripartum cardiomyopathy (PPCM) is a deterioration in cardiac function that occurs in pregnant women during the last month or in the months following their pregnancy. This disorder can occur in women with no prior history ...

Diseases, Conditions, Syndromes created Apr 24, 2013 | popularity not rated yet | comments 0

Gene replacement in pigs ameliorates cystic fibrosis-associated intestinal obstruction

Cystic fibrosis (CF) is caused by mutations in CFTR and is characterized by dysfunction of the lungs, liver, pancreas, and intestines. Approximately 15% of babies with CF are born with an obstruction of the small intestine ...

Diseases, Conditions, Syndromes created May 08, 2013 | popularity not rated yet | comments 0

Alzheimer's disease is associated with removal of the synaptic protein ADAM10

Alzheimer's disease is characterized by the accumulation of neurotoxic β-amyloid peptide (A-beta). ADAM10, a protein that resides in the neural synapses, has previously been shown to prevent the formation of A-beta.

Alzheimer's disease & dementia created May 08, 2013 | popularity not rated yet | comments 0

HPV leaves its mark in oropharyngeal squamous cell carcinoma

Oropharyngeal squamous cell carcinoma (OPSCC) is a form of cancer that affects the cells lining the middle part of the throat, including the soft palate, the base of the tongue, the tonsils, and the pharynx.

Cancer created May 01, 2013 | popularity not rated yet | comments 0

Searching for therapeutic synergy in primary effusion lymphoma

Primary effusion lymphoma (PEL) is a rare, fatal form of aggressive B-cell lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV). The disease most commonly occurs in immunocompromised patients, such as those with ...

Cancer created May 01, 2013 | popularity not rated yet | comments 0

No rebirth for insulin secreting pancreatic beta cells

Pancreatic beta cells store and release insulin, the hormone responsible for stimulating cells to convert glucose to energy. The number of beta cells in the pancreas increases in response to greater demand for insulin or ...

Medical research created Apr 24, 2013 | popularity not rated yet | comments 0