Public Library of Science

The Public Library of Science (PLOS) was founded in 2000 by biomedical scientists Harold E. Varmus, Patrick O. Brown and Michael Eisen for the purpose of granting open access to the public about scientific research papers. An open letter was sent to scientific publishers encouraging them to all distribution of their research literature through an on-line publication like the National Library of Medicine's PubMed Central. In response to a less than receptive response, PLOS launched a nonprofit scientific and medical publishing venture in 2003. PLOS articles are available free on-line and appear immediately on the web site for no charge. PLOS received start-up funds from the Gordon and Betty Moore Foundations and has received various other foundation endowments for their not for profit enterprise.

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Genome sequencing illuminates rare Aicardi syndrome

As my inbox fills with ever more updates on the number of human genomes sequenced and the plummeting time and cost of next next next generation sequencing, I find myself hitting delete more and more often. Instead, I'm drawn ...

Jul 02, 2015
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Face shape is in the genes

Many of the characteristics that make up a person's face, such as nose size and face width, stem from specific genetic variations, reports John Shaffer of the University of Pittsburgh in Pennsylvania, and colleagues, in a ...

Aug 25, 2016
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Defining clinical vs. statistical significance

The practice of null hypothesis testing has traditionally been used to interpret the results of studies in a wide variety of scientific fields. Briefly, significance testing involves the calculation of an outcome statistic, ...

Jun 25, 2015
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Deciphering dark and bright

The human sensory systems contend with enormous diversity in the natural world. But it has been known for a long time the brain is adapted to exploit statistical regularities that nonetheless arise amongst this diversity. ...

May 28, 2015
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