The Wistar Institute

The Wistar Institute is a biomedical center, with a focus on cancer research and vaccine development. It is located in the University City section of Philadelphia, Pa. Founded in 1892 as the first independent, nonprofit, biomedical research institute in the country, Wistar has held the Cancer Center designation from the National Cancer Institute since 1972. Wistar has more than thirty laboratories, which are home to three research programs: a gene expression and regulation program, a molecular and cellular oncogenesis program, and an immunology program. The Institute's research program on cancer includes the following goals and areas: Wistar's training and outreach initiatives include: The Wistar Institute was founded in 1892 as the nation’s first independent medical research facility. It is named for Caspar Wistar, M.D., a prominent Philadelphia physician who began his medical practice in 1787. Dr. Wistar was the author of the first American anatomy textbook. To augment his medical lectures and illustrate comparative anatomy, Dr. Wistar began a collection of dried, wax-injected, and preserved human specimens.

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Mechanism of an effective MEK inhibitor identified

Understanding the effects of certain targeted therapies on antitumor immunity is necessary to design combined interventions for more effective cancer treatment. In the past, data have shown that trametinib, an FDA-approved ...

Nov 01, 2016
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Estrogen signaling impacted immune response in cancer

While the role of estrogen signaling in tumor development is well understood in breast and ovarian cancer, its role in anti-tumor immunity has not been extensively studied. However, new research from The Wistar Institute ...

Oct 17, 2016
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Two key proteins preserve vital genetic information

Cancer is often driven by various genetic mutations that are acquired through changes to a person's DNA over time. These alterations can occur at the chromosome level if the proteins are not properly organized and segregated ...

Aug 22, 2016
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