Thomas Jefferson University

Immunology

Eye injury sets immune cells on surveillance to protect the lens

The lens of the eye is an unusual organ. Unlike most of the body's organs, blood vessels don't reach the lens. If they did, they'd obscure our vision and we wouldn't be able to see. The lack of vasculature led scientists ...

Oncology & Cancer

MicroRNA exhibit unexpected function in driving cancer

Researchers long thought that only one strand of a double-stranded microRNA can silence genes. Though recent evidence has challenged that dogma, it's unclear what the other strand does, and how the two may be involved in ...

Oncology & Cancer

Finding familiar pathways in kidney cancer

p53 is the most famous cancer gene, not least because it's involved in causing over 50% of all cancers. When a cell loses its p53 gene—when the gene becomes mutated—it unleashes many processes that lead to the uncontrolled ...

Neuroscience

Stabilizing neuronal branching for healthy brain circuitry

Neurons form circuits in our brain by creating tree-like branches to connect with each other. Newly forming branches rely on the stability of microtubules, a railway-like system important for the transport of materials in ...

Oncology & Cancer

Hole-forming protein may suppress tumor growth

Sometimes cells need to die. The process of cell death is encoded within the genome of all higher organisms to kill off cancerous cells, and as a normal part of development to shape a mass of embryonic cells into the organism ...

Medical research

New role for death molecule

Cellular death is vital for health. Without it, we could develop autoimmune diseases or cancers. But a cell's decision to self-destruct is tightly regulated, so that it only happens to serve the best interests of the body. ...

Oncology & Cancer

How melanoma evades targeted therapies

Melanoma is the leading cause of death from skin cancer. Many patients develop metastatic disease that spreads to other parts of the body. One commonly used targeted therapy for metastatic melanomas works by attacking melanomas ...

Medical research

Study opens new therapeutic avenue for mitochondria malfunction

A surprising offender has been emerging to drive the progression of Parkinson's, Alzheimer's, Huntington's and other neurodegenerative diseases: calcium. Calcium controls the production of fuel in mitochondria, the cell's ...

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