The one-size-fits-all approach to early stage breast cancer creates a paradox: Millions of dollars are spent on unnecessary surgeries and radiation to treat women with low-risk 'in situ' lesions, an estimated 85% of which ...
Apr 3, 2017
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222
Using red blood cells modified to carry disease-specific antigens, scientists in the laboratories of Hidde Ploegh (former Whitehead Member, currently Boston Children's Hospital) and Harvey Lodish (Whitehead Founding Member) ...
Mar 6, 2017
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534
Cancer is a heterogeneous disease, with myriad distinct subtypes that differ in their genetic roots. As a result, cancers rely on varied pathways for survival—and respond differently to anticancer agents. The challenge ...
Feb 2, 2017
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34
Parkinson's disease (PD) and other "synucleinopathies" are known to be linked to the misfolding of alpha-synuclein protein in neurons. Less clear is how this misfolding relates to the growing number of genes implicated in ...
Jan 25, 2017
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126
One of the most significant ways in which the human brain is unique is the size and structure of the cerebral cortex. But what drives the growth of the human cortex, likely the foundation for our unique intellectual abilities?
Dec 29, 2016
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65
The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs. But Whitehead Institute researchers have found a mechanism underlying this resistance—a ...
Dec 27, 2016
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61
Investigators from Whitehead Institute, the Ragon Institute of MGH, MIT and Harvard and the Broad Institute of MIT and Harvard have used CRISPR-Cas9 gene-editing technology to identify three promising new targets for treatment ...
Dec 19, 2016
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70
In research published this week in the Proceedings of the National Academy of Sciences (PNAS), researchers at the Whitehead Institute for Biomedical Research and the Picower Institute for Learning and Memory at Massachusetts ...
Oct 31, 2016
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29
Parental imprinting—a form of gene control passed down from parents to offspring—is far more dynamic than previously thought and may contribute to changes in the brain and other tissues over time. This finding by Whitehead ...
Sep 20, 2016
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65
Using a novel method, Whitehead Institute researchers have determined how a non-coding mutation identified in genome-wide association studies (GWAS) can contribute to sporadic Parkinson's disease (PD). The approach could ...
Apr 20, 2016
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