Whitehead Institute for Biomedical Research
Researchers expose new vulnerabilities in the security of personal genetic information
Using only a computer, an Internet connection, and publicly accessible online resources, a team of Whitehead Institute researchers has been able to identify nearly 50 individuals who had submitted personal genetic material ...
Genetics
Jan 17, 2013 |
4.3 / 5 (4) |
2
|
Aggressive cancer exploits MYC oncogene to amplify global gene activity
Whitehead Institute researchers have determined the mechanism used by c-Myc to increase the expression of all active genes in cancer cells. Elevated levels of c-Myc are linked to increased rates of metastasis, disease recurrence, ...
Cancer
Sep 27, 2012 |
not rated yet |
0
|
High levels of master heat shock protein linked to poor prognosis in breast cancer patients
Whitehead Institute scientists report that patients whose estrogen receptor (ER)-positive breast cancers have high levels of the ancient cellular survival factor heat shock factor 1 (HSF1) experience poor ...
Cancer
Oct 31, 2011 |
not rated yet |
0
|
Yeast model connects Alzheimer's disease risk and amyloid beta toxicity
In a development that sheds new light on the pathology of Alzheimer's disease (AD), a team of Whitehead Institute scientists has identified connections between genetic risk factors for the disease and the ...
Medical research
Oct 27, 2011 |
5 / 5 (4) |
0
|
Genetic master controls expose cancers' Achilles' heel
In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed "super-enhancers" that control cell state ...
Cancer
Apr 11, 2013 |
4.8 / 5 (6) |
0
|
Protective prion keeps yeast cells from going it alone
Most commonly associated with such maladies as "mad cow disease" and Creutzfeldt-Jakob disease, prions are increasingly recognized for their ability to induce potentially beneficial traits in a variety of organisms, yeast ...
Medical research
Mar 28, 2013 |
5 / 5 (1) |
0
|
Long noncoding RNAs control development of fat cells
Whitehead Institute researchers have identified a previously unrecognized layer of genetic regulation that is necessary for the generation of undesirable white fat cells. When this regulation is disrupted, white fat cells ...
Overweight and Obesity
Feb 13, 2013 |
5 / 5 (2) |
0
|
Modified antibodies trigger immune response, point to novel vaccine design strategies
In an approach with the potential to aid therapeutic vaccine development, Whitehead Institute scientists have shown that enzymatically modified antibodies can be used to generate highly targeted, potent responses from cells ...
Medical research
Jan 07, 2013 |
5 / 5 (1) |
0
|
Cell surface transporters exploited for cancer drug delivery
Whitehead Institute scientists report that certain molecules present in high concentrations on the surfaces of many cancer cells could be exploited to funnel lethal toxic molecules into the malignant cells. In such an approach, ...
Genetics
Dec 02, 2012 |
5 / 5 (2) |
0
|
Whitehead scientists identify major flaw in standard approach to global gene expression analysis
Whitehead Institute researchers report that common assumptions employed in the generation and interpretation of data from global gene expression analyses can lead to seriously flawed conclusions about gene activity and cell ...
Genetics
Oct 25, 2012 |
not rated yet |
0
|
Study reveals rate at which key genetic deletions contribute to male infertility
A large-scale analysis of Y chromosomes from more than 20,000 men finds that two spontaneously recurring deletions along a complex region of the Y chromosome are responsible for approximately 8% of cases of failed sperm production.
Genetics
Oct 25, 2012 |
5 / 5 (1) |
0
|
Protein found to regulate red blood cell size and number
The adult human circulatory system contains between 20 and 30 trillion red blood cells (RBCs), the precise size and number of which can vary from person to person. Some people may have fewer, but larger RBCs, while others ...
Genetics
Aug 28, 2012 |
not rated yet |
1
|
Heat-shock factor reveals its unique role in supporting highly malignant cancers
Whitehead Institute researchers have found that increased expression of a specific set of genes is strongly associated with metastasis and death in patients with breast, colon, and lung cancers. Not only could this finding ...
Cancer
Aug 02, 2012 |
not rated yet |
0
|
Long intervening non-coding RNAs play pivotal roles in brain development
Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles during embryonic brain development in zebrafish. They also show that the human versions of the lincRNAs ...
Medical research
Dec 22, 2011 |
5 / 5 (2) |
0
|
How major signaling pathways are wired to our genome gives new insight into disease processes
Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. In this way, signaling pathways are targeted to genes that are most relevant to each ...
Medical research
Oct 27, 2011 |
not rated yet |
0
|
