Defective cellular waste removal explains why Gaucher patients often develop Parkinson's disease
Gaucher disease causes debilitating and sometimes fatal neurodegeneration in early childhood. Recent studies have uncovered a link between the mutations responsible for Gaucher disease and an increased risk ...
Parkinson's & Movement disorders
May 23, 2013 |
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Of enzymes and aging: Tryptophan metabolism plays key role in aging and age-related neurological diseases
(Medical Xpress)—In the battle against aging and age-related neurological diseases such as Parkinson's and Alzheimer's, a key factor has long appeared to be the toxicity of proteins which tend to aggregate. ...
Medical research
Oct 05, 2012 |
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Study reveals probable role of Parkinson's protein in healthy brain
(Medical Xpress)—Researchers at the Stanford University School of Medicine have exposed the possible function, in the healthy brain, of a mysterious molecule that has been strongly implicated in Parkinson's ...
Parkinson's & Movement disorders
May 01, 2013 |
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New clue to Parkinson's: Shape of key protein surprises researchers
A new study finds that a protein key to Parkinson's disease has likely been mischaracterized. The protein, alpha-synuclein, appears to have a radically different structure in healthy cells than previously thought, challenging ...
Medical research
Aug 14, 2011 |
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Excess protein linked to development of Parkinson's disease
Researchers at the University of California, San Diego School of Medicine say overexpression of a protein called alpha-synuclein appears to disrupt vital recycling processes in neurons, starting with the ...
Parkinson's & Movement disorders
Feb 07, 2013 |
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Scientists identify 'clean-up' snafu that kills brain cells in Parkinson's disease
Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered how the most common genetic mutations in familial Parkinson's disease damage brain cells. The study, which published online today in ...
Parkinson's & Movement disorders
Mar 03, 2013 |
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Curcumin shows promise in attacking Parkinson's disease
Curcumin, a compound found in the spice turmeric, is proving effective at preventing clumping of a protein involved in Parkinson's disease, says a Michigan State University researcher.
Parkinson's & Movement disorders
Mar 20, 2012 |
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Rice opens new window on Parkinson's disease
(Medical Xpress)—Rice University scientists have discovered a new way to look inside living cells and see the insoluble fibrillar deposits associated with Parkinson's disease.
Parkinson's & Movement disorders
Dec 17, 2012 |
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Research shows genetic evidence that new therapies targeting Parkinson's disease may cause harm
(Medical Xpress)—NorthShore University HealthSystem (NorthShore) and Mayo Clinic researchers have partnered on a study that shows genetic and clinical evidence that therapies targeting the expression of alpha-synuclein—a ...
Parkinson's & Movement disorders
Mar 21, 2013 |
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Mechanism that leads to sporadic Parkinson's disease identified
Researchers in the Taub Institute at Columbia University Medical Center (CUMC) have identified a mechanism that appears to underlie the common sporadic (non-familial) form of Parkinson's disease, the progressive movement ...
Parkinson's & Movement disorders
Sep 25, 2012 |
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Seeds of destruction in Parkinson's disease: Spread of diseased proteins kills neurons
New research suggests that small "seed" amounts of diseased brain proteins can be taken up by healthy neurons and propagated within them to cause neurodegeneration. The research, published by Cell Press in the October 6 issue ...
Neuroscience
Oct 05, 2011 |
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Parkinson's protein causes disease spread in animal model, suggesting way disorder progresses over time in humans
(Medical Xpress) -- Penn researchers have shown that brain tissue from a Parkinson's disease mouse model , as well as synthetically produced disease protein fibrils, injected into young, symptom-free PD mice ...
Parkinson's & Movement disorders
Apr 17, 2012 |
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Colonoscopy or flexible sigmoidoscopy may be used to predict Parkinson's
Two studies by neurological researchers at Rush University Medical Center suggest that, in the future, colonic tissue obtained during either colonoscopy or flexible sigmoidoscopy may be used to predict who will develop Parkinson's ...
Parkinson's & Movement disorders
May 15, 2012 |
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Study first to link mitochondrial dysfunction and alpha-Synuclein multiplication in human fibroblasts
A new study in the Journal of Parkinson's Disease shows for the first time the effects of α-Synuclein (α-syn) gene multiplication on mitochondrial function and susceptibility to oxidative stress in human tissue ...
Diseases, Conditions, Syndromes
Oct 06, 2011 |
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SUMO defeats protein aggregates that typify Parkinson's disease
A small protein called SUMO might prevent the protein aggregations that typify Parkinson's disease (PD), according to a new study in the July 11, 2011, issue of The Journal of Cell Biology.
Parkinson's & Movement disorders
Jul 11, 2011 |
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