Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous system. Apart from dynamic ...
Aug 18, 2021
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A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, ...
Jul 22, 2021
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University of California, Irvine biologists have developed a new genetically engineered mouse model, that unlike its predecessors, is based on the most common form of Alzheimer's disease. The advance holds promise for making ...
Apr 27, 2021
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One of the characteristic hallmarks of Alzheimer's disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they've largely failed in clinical trials. ...
Apr 15, 2021
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Findings of a study by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that increasing expression of a gene known as ABCC1 could not only reduce the deposition of a hard plaque ...
Apr 14, 2021
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Researchers at the University of California San Diego School of Medicine and Massachusetts General Hospital have identified a new drug that could prevent Alzheimer's disease by modulating, rather than inhibiting, a key enzyme ...
Mar 2, 2021
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Researchers at University of California San Diego School of Medicine have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons ...
Feb 19, 2021
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Alzheimer's disease is the leading cause of dementia worldwide and a major cause of disability. Now, researchers at Osaka University and Hokkaido University have shown that repeated precipitation-dissolution events of salt ...
Jul 27, 2020
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A gene has been discovered that can naturally suppress the signs of Alzheimer's Disease in human brain cells, in research led by Queen Mary University of London. The scientists have also developed a new rapid drug-screening ...
Jul 9, 2020
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A newly identified compound is a promising candidate for inhibiting the production of amyloids, the abnormal proteins that form toxic clumps, called fibrils, inside the brains of patients with Alzheimer's disease. As published ...
Feb 3, 2020
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