News tagged with animal model

Related topics: mouse model · cancer cells · nerve cells · proceedings of the national academy of sciences · cells

A new biomarker for nerve cell damage

Scientists at the German Center for Neurodegenerative Diseases, the Hertie Institute for Clinical Brain Research and the University of Tübingen have identified proteins in the blood and cerebrospinal fluid that reflect nerve ...

Jun 09, 2016
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A macaque model of HIV infection

Researchers have taken a major step toward developing a better animal model of human AIDS. Such a model could greatly improve researchers' ability to evaluate potential strategies for preventing and treating the disease.

Jun 02, 2016
popularity27 comments 0

Gene mutations shown to cause form of HSP

Scientists at the Montreal Neurological Institute and Hospital (MNI) have identified novel gene mutations that cause hereditary spastic paraplegia (HSP), a step forward in efforts to treat this debilitating disease.

May 10, 2016
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Fireflies light the way to female HIV transmission

Finding the vulnerable points where HIV enters the female reproductive tract is like searching for needles in a haystack. But Northwestern Medicine scientists have solved that challenge by creating a glowing map of the very ...

Apr 27, 2016
popularity61 comments 0

Animal model

An animal model is a non-human animal that has a disease or injury that is similar to a human condition. These test conditions are often termed as animal models of disease. The use of animal models allows researchers to investigate disease states in ways which would be inaccessible in a human patient, performing procedures on the non-human animal that imply a level of harm that would not be considered ethical to inflict on a human.

In order to serve as a useful model, a modeled disease must be similar in etiology (mechanism of cause) and function to the human equivalent. Animal models are used to learn more about a disease, its diagnosis and its treatment. For instance, behavioral analogues of anxiety or pain in laboratory animals can be used to screen and test new drugs for the treatment of these conditions in humans. A 2000 study found that animal models predicted human toxicity in 71% of cases, with 63% for nonrodents alone and 43% for rodents alone.

Animal models of disease can be spontaneous (naturally occurring in animals), or be induced by physical, chemical or biological means. For example,

The increase in knowledge of the genomes of non-human primates and other mammals that are genetically close to humans is allowing the production of genetically engineered animal tissues, organs and even animal species which express human diseases, providing a more robust model of human diseases in an animal model.

Animal models observed in the sciences of psychology and sociology are often termed animal models of behavior.

In quantitative genetics, the term animal model is used to refer to statistical models in which phenotypic variance is compartmentalised into environmental, genetic and sometimes maternal effects. Such animal models are also known as "mixed models".

This text uses material from Wikipedia, licensed under CC BY-SA

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