News tagged with apoptosis
Challenging a half-century-old theory about why chemotherapy agents target cancer, scientists at Dana-Farber Cancer Institute have devised a test that can predict how effective the drugs will be by determining whether a patient's ...
Cancer Oct 27, 2011 | 5 / 5 (6) | 0 |
A team led by scientists at The Scripps Research Institute has discovered key elements of a strategy commonly used by tumor cells to survive when they spread to distant organs. The finding could lead to drugs that could inhibit ...
Cancer Jan 26, 2012 | 5 / 5 (3) | 0 |
(Medical Xpress)—Membrane fusion is a highly regulated event, both inside cells, and between them. From the moment a sperm first fuses with an egg, subsequent developmental events depend upon its proper ...
Medical research Apr 26, 2013 | 4.3 / 5 (3) | 0 |
(Medical Xpress) -- Though apoptosis is hardly a household word, its been estimated that more than half of all diseases for which we have no suitable treatment are related to malfunctions in apoptosis, ...
Medical research Jun 22, 2011 | 5 / 5 (2) | 0 |
Glioblastoma, a lethal brain cancer, is one of the most resistant to available therapies and patients typically live approximately 15 months.
Cancer Jan 24, 2012 | 5 / 5 (1) | 0
A large change in the volume of a cell, from its basal level, is detrimental to its health. Therefore, our cells are equipped with mechanisms to maintain their constant volume. When a cell detects an environmental change ...
Medical research Mar 08, 2012 | 5 / 5 (1) | 0
(HealthDay) -- Bone marrow mesenchymal stem cells (BMMSCs) activate a mechanism involving coupling of FAS/FAS ligand to induce T cell apoptosis and immune tolerance, according to an experimental study published ...
Medical research May 02, 2012 | 5 / 5 (1) | 0
(Medical Xpress)—A protein called Myc, commonly found at high levels inside cancer cells, fuels the disease by allowing cells to override their in-built self-destruct mechanisms, according to two new studies by US scientists.
Cancer Oct 01, 2012 | 5 / 5 (1) | 0 |
Many medical issues affect nerves, from injuries in car accidents and side effects of chemotherapy to glaucoma and multiple sclerosis. The common theme in these scenarios is destruction of nerve axons, the ...
Neuroscience May 09, 2013 | 5 / 5 (1) | 0 |
Apoptosis ( /ˌæpəˈtoʊsɪs/) is the process of programmed cell death (PCD) that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation. (See also Apoptosis DNA fragmentation.) Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytic cells are able to engulf and quickly remove before the contents of the cell can spill out onto surrounding cells and cause damage.
In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis, in general, confers advantages during an organism's life cycle. For example, the differentiation of fingers and toes in a developing human embryo occurs because cells between the fingers apoptose; the result is that the digits are separate. Between 50 and 70 billion cells die each day due to apoptosis in the average human adult. For an average child between the ages of 8 and 14, approximately 20 billion to 30 billion cells die a day.
Research in and around apoptosis has increased substantially since the early 1990s. In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in an extensive variety of diseases. Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer.
For more information about Apoptosis, read the full article at
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