Clinical decline in Alzheimer's requires plaque and proteins
According to a new study, the neuron-killing pathology of Alzheimer's disease (AD), which begins before clinical symptoms appear, requires the presence of both amyloid-beta (a-beta) plaque deposits and elevated levels of ...
Neuroscience
Apr 23, 2012 |
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Persistent ocular tremors appear to be associated with Parkinson's disease
Persistent ocular tremors that prevent eye stability during fixation appear to be common among patients with Parkinson disease (PD) suggesting that precise oculomotor testing could provide an early physiological biomarker ...
Parkinson's & Movement disorders
Apr 09, 2012 |
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Study examines immunotherapy and cerebrospinal fluid biomarkers in patients with Alzheimer's disease
Immunotherapy with the antibody bapineuzumab in patients with mild to moderate Alzheimer disease resulted in decreases in a cerebrospinal fluid biomarker, which may indicate downstream effects on the degenerative process, ...
Alzheimer's disease & dementia
Apr 02, 2012 |
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Study examines link between blood biomarkers and risk of Alzheimer's disease
A meta-analysis of previously published studies found that the ratio of blood plasma amyloid-β (Aβ) peptides Aβ42:Aβ40 was significantly associated with development of Alzheimer disease and dementia, according ...
Neuroscience
Mar 26, 2012 |
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Asian origins of Machado-Joseph disease revealed
(Medical Xpress) -- Knowledge of a disease prevalent among Northern Territory Indigenous communities has been overhauled thanks to research contributed by the University of Sydney's Garth Nicholson.
Diseases, Conditions, Syndromes
Mar 09, 2012 |
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Brain-imaging technique predicts who will suffer cognitive decline over time
Cognitive loss and brain degeneration currently affect millions of adults, and the number will increase, given the population of aging baby boomers. Today, nearly 20 percent of people age 65 or older suffer ...
Neuroscience
Feb 13, 2012 |
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Revised criteria could reclassify many with mild Alzheimer dementia
Many patients currently diagnosed with very mild or mild Alzheimer disease dementia could potentially be reclassified as having mild cognitive impairment (MCI) under revised criteria for that condition, according to a report ...
Alzheimer's disease & dementia
Feb 06, 2012 |
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Neuropathy patients more likely to receive high-cost, screening instead of more effective tests
Researchers at the University of Michigan analyzed the tremendous cost of diagnosing peripheral neuropathy and found that less expensive, more effective tests are less likely to be used.
Diseases, Conditions, Syndromes
Jan 23, 2012 |
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Active lifestyle associated with less Alzheimer disease-related brain change among persons with APOE epsilon4 genotype
A sedentary lifestyle is associated with greater cerebral amyloid deposition, which is characteristic of Alzheimer’s disease (AD), among cognitively normal individuals with the ε4 allele of the apolipoprotein E ...
Diseases, Conditions, Syndromes
Jan 16, 2012 |
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Demographic, clinical factors appear associated with survival in patients with Parkinson's disease
Demographics and clinical factors appear to be associated with survival in patients with Parkinson disease (PD), and the presence of dementia is associated with a significant increase in mortality, according to a report in ...
Parkinson's & Movement disorders
Jan 02, 2012 |
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A second 'bad' gene is linked to damaged cell buildup, paralysis in ALS
Following a major Northwestern Medicine breakthrough that identified a common converging point for all forms of amyotrophic lateral sclerosis (ALS and Lou Gehrig's disease), a new finding from the same scientists further ...
Genetics
Nov 21, 2011 |
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Small study shows association between medication and reduction in brain amyloid levels related to AD
Although it is a small study and more clinical trials are needed, treatment with the medication gantenerumab appeared to result in a reduction in brain amyloid levels in patients with Alzheimer disease, according to a report ...
Neuroscience
Oct 10, 2011 |
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Marker for Alzheimer's disease rises during day and falls with sleep
A marker for Alzheimer's disease rises and falls in the spinal fluid in a daily pattern that echoes the sleep cycle, researchers at Washington University School of Medicine in St. Louis have found.
Alzheimer's disease & dementia
Sep 26, 2011 |
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Study finds no link between intracerebral hemorrhage and statin use among patients with prior stroke
Among patients who have had an ischemic stroke, use of cholesterol-lowering statin medications is not associated with subsequent intracerebral hemorrhage (bleeding in the brain), according to a report published Online First ...
Neuroscience
Sep 12, 2011 |
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Study evaluates intranasal insulin therapy for adults with mild cognitive impairment or Alzheimer's
Intranasal insulin therapy appears to provide some benefit for cognitive function in patients with amnestic mild cognitive impairment and Alzheimer disease, according to a report published Online First today by Archives of ...
Neuroscience
Sep 12, 2011 |
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