Scientists uncover a novel cooperative effort to stop cancer spread
(Medical Xpress)—Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered a group of what have been considered relatively minor regulators in the body that band together to suppress the ...
Cancer
Nov 28, 2012 |
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Targeting protein could prevent metastasis of cancer cells
(Medical Xpress)—Researchers at King's College London have uncovered a protein required by cancer cells to spread to other parts of the body, highlighting it as a potential target for future treatments ...
Cancer
Nov 14, 2012 |
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Lactation protein suppresses tumors and metastasis in breast cancer, scientists discover
A protein that is necessary for lactation in mammals inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis, according to research conducted at the University at Buffalo and Princeton ...
Cancer
Oct 24, 2012 |
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Discovery reveals important clues to cancer metastasis
In recent years investigators have discovered that breast tumors are influenced by more than just the cancer cells within them. A variety of noncancerous cells, which in many cases constitute the majority ...
Cancer
Oct 11, 2012 |
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Endotrophin links obesity to breast cancer progression
Fat cells (adipocytes) surround breast tumors and contribute to tumor growth by expressing factors that aid oncogenesis. Col6 is a protein that is highly expressed in adipocytes and its expression is further increased in ...
Cancer
Oct 08, 2012 |
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LIFR protein suppresses breast cancer metastasis
A receptor protein suppresses local invasion and metastasis of breast cancer cells, the most lethal aspect of the disease, according to a research team headed by scientists from The University of Texas MD Anderson Cancer ...
Cancer
Sep 25, 2012 |
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How breast cancer spreads: Researchers find key to lymph node metastasis in mice
The invasion of cancer cells into the lymph vessels that connect the breast to surrounding lymph nodes is the first step leading to the metastasis, or spread, of cancer throughout the body. Metastasis is the primary cause ...
Cancer
Sep 10, 2012 |
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Tension on gut muscles induces cell invasion in zebrafish intestine, mimicking cancer metastasis
The stiffness of breast tissue is increasingly recognized as an important factor explaining the onset of breast cancer. Stiffening induces molecular changes that promote cancerous behavior in cells. Bioengineering ...
Cancer
Sep 07, 2012 |
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Modeling metastasis
Cancer metastasis, the escape and spread of primary tumor cells, is a common cause of cancer-related deaths. But metastasis remains poorly understood. Studies indicate that when a primary tumor breaks through ...
Cancer
Aug 24, 2012 |
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LPA1 inhibition induces metastatic dormancy in mouse models of breast cancer
A lysophosphatidic acid receptor 1 (LPAR1) inhibitor, known as Debio-0719, suppresses the development of metastases in mice by inducing cancer cell dormancy, according to a study published August 21 in the Journal of the Na ...
Cancer
Aug 21, 2012 |
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TRPM7 protein key to breast cancer metastasis in animal models
The protein transient receptor potential melastatin-like 7 (TRPM7) is a critical determinant of breast cancer cell metastasis, according to study results published in Cancer Research, a journal of the American Association for Ca ...
Cancer
Aug 07, 2012 |
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Researchers find driver of breast cancer stem cell metastasis
The finding involves the cancer gene RhoC, which has previously been shown to promote metastasis of many types of cancer. RhoC levels increase as breast cancer progresses and high levels of RhoC are associated with worse ...
Cancer
Jul 24, 2012 |
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Stress fuels breast cancer metastasis to bone
Stress can promote breast cancer cell colonization of bone, Vanderbilt Center for Bone Biology investigators have discovered.
Cancer
Jul 17, 2012 |
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Combination treatment with lapatinib and pazopanib doesn't improve outcomes for patients with IBC
Inflammatory breast cancer is a very aggressive type of cancer associated with early metastasis and poor survival rates, and the prognosis is even worse for patients with tumors expressing the ErbB2 receptor. The ErbB2-inhibiting ...
Cancer
Jun 01, 2012 |
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Heparin-like compounds inhibit breast cancer metastasis to bone
Researchers from VTT Technical Research Centre of Finland have in collaboration with the University of Turku, Indiana University and two Finnish companies, Biotie Therapies Corp. and Pharmatest Services Ltd, discovered a ...
Cancer
May 21, 2012 |
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