One of the most extensively studied genes in cancer, TP53 is well known for its role as a tumor suppressor. It senses cellular stress or damage, and in response stops cell division or initiates cell death, thereby preventing ...
Jul 30, 2019
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285
For years, researchers have been trying to target a gene called MYC that is known to drive tumor growth in multiple cancer types when it is mutated or over-expressed, but hitting that target successfully has proven difficult. ...
Jul 1, 2019
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4
The human immune system relies on a delicate balance of finely tuned cell types that keep germs and cancerous cells in check. In cancer and chronic infections this balance can be disrupted, resulting in immune system dysfunction ...
Jun 17, 2019
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90
A systematic examination of the tumor and the tissue surrounding it—particularly normal cells in that tissue, called fibroblasts—has revealed a new treatment target that could potentially prevent the rapid dissemination ...
May 1, 2019
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210
How do mobile cell types like leukocytes or metastatic cancer cells reach their place of action during immune surveillance or cancer dissemination, respectively? The research group around Michael Sixt at IST Austria has now ...
Apr 3, 2019
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16
Cutting-edge sequencing technology has revolutionized cancer diagnosis and since identified several so-called cancer driver genomic aberrations. This has led to the development of an extensive and powerful arsenal of anti-cancer ...
Mar 20, 2019
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27
University of Minnesota researchers have developed a way to study cancer cells which could lead to new and improved treatment. They have developed a new way to study these cells in a 3-D in vitro model (i.e. in a culture ...
Feb 11, 2019
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30
Mutations that cause oesophageal adenocarcinoma (OAC) have been mapped in unprecedented detail—unveiling that more than half could be targeted by drugs currently in trials for other cancer types.
Feb 4, 2019
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37
Cancer scientists led by principal investigator Dr. Daniel De Carvalho at Princess Margaret Cancer Centre have combined "liquid biopsy", epigenetic alterations and machine learning to develop a blood test to detect and classify ...
Nov 14, 2018
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157
Scientists have arrived at a key understanding about how cancers in individual patients spread, or metastasize, a study from the Stanford University School of Medicine and other collaborating institutions reports.
Sep 6, 2018
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116
