News tagged with cell proliferation

Normal gene hinders breast cancer chemotherapy

Presence of normal p53, a tumor suppressor gene, instead of a mutated version, makes breast cancer chemotherapy with doxorubicin less effective. The preclinical study led by MD Anderson scientists was published today in the ...

Jun 11, 2012
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Probing the mechanism of ADAM28-mediated cancer metastasis

ADAM28, a metalloproteinase belonging to the ADAM gene family, cleaves the von Willebrand factor (VWF) and inhibits VWF-mediated cancer cell apoptosis, thereby enhancing lung metastases, so inhibiting its expression gives ...

Jun 08, 2012
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Immune-response genes affecting breast tumor eradication

Breast cancer patients whose tumors express high levels of genes related to immune response are more likely to have their tumor completely eradicated by pre-operative chemotherapy compared to patients with low expression ...

May 03, 2012
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New genetic mechanism of immune deficiency discovered

Researchers at National Jewish Health have discovered a novel genetic mechanism of immune deficiency. Magdalena M. Gorska, MD, PhD, and Rafeul Alam, MD, PhD, identified a mutation in Unc119 that causes immunodeficiency known ...

Apr 20, 2012
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