Scientists have developed new drug compounds that thwart the pro-cancer activity of FOXM1, a transcription factor that regulates the activity of dozens of genes. The new compounds suppress tumor growth in human cells and ...
Jan 7, 2020
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Researchers at the University of Toronto have identified a key protein that supports the growth of many colorectal cancers. The study, which will be published December 27 in the Journal of Cell Biology, reveals that a protein ...
Dec 27, 2019
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Palbociclib is clinically approved for use in treating breast cancer, but according to a new study, the molecular mechanism behind the drug's effectiveness is not what scientists had thought it was.
Dec 18, 2019
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Targeted, highly effective cancer treatments often produce debilitating side effects. This is the case with one commonly used therapy which works by blocking the epidermal growth factor receptor (EGFR), a protein that stimulates ...
Dec 12, 2019
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With unexpected findings about a protein that's highly expressed in fat tissue, scientists at Scripps Research have opened the door to critical new understandings about obesity and metabolism. Their discovery, which appears ...
Nov 21, 2019
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Glioblastoma multiforme, or GBM, is the most frequently occurring and gravest primary tumor of the central nervous system in adults. Poor survival rates among patients with GBM are associated with the development of resistance ...
Nov 14, 2019
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Scientists from Basel have investigated the activity of stem cells in the brain of mice and discovered a key mechanism that controls cell proliferation. According to the researchers, the gene regulator Id4 controls whether ...
Aug 28, 2019
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While researchers have a basic understanding of how primary cancer cells grow, less is known about metastasis, the deadly process by which cancers spread. A team led by Dr. Paul Krebsbach, dean of UCLA's School of Dentistry ...
Jul 11, 2019
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Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, is the fifth most common cause of death from cancer in the UK and the third in the United States. Deaths from PDAC outnumber those from breast ...
Jun 19, 2019
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Results from a study spearhead by researchers at the Vall d´Hebron Institute of Oncology (VHIO), show that the blockade of the multi-functional cytokine LIF induces tumor-infiltrating T cells to target and eliminate cancer. ...
Jun 11, 2019
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