Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases could also work ...
Jan 29, 2013
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Stem cells of the aging bone marrow recycle their own molecules to survive and keep replenishing the blood and immune systems as the body ages, researchers at UC San Francisco (UCSF) have discovered.
Feb 14, 2013
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Researchers at Fox Chase Cancer Center have identified a host of small molecules critical to metabolism in cells of triple-negative breast cancer—one of the least understood groups of breast cancer. These molecules, called ...
Apr 9, 2013
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A new study published in Cell Metabolism by the research group of Professor Nils-Göran Larsson, at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, shows that so-called supercomplexes have no ...
Aug 28, 2023
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An international team led by researchers at UC Davis has shown that the cyclin B1/Cdk1 protein complex, which plays a key role in cell division, also boosts the mitochondrial activity to power that process. This is the first ...
Apr 17, 2014
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A study published in the journal of Biochemical Pharmacology suggests major flavonoid quercetin is beneficial in reducing the risk of cardiovascular disease (CVD).
Jan 9, 2013
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An article published on the journal Nature describes the major role that Pyruvate dehydrogenase (PDH) —an enzyme of cellular energy metabolism— plays in the regulation of the cellular senescence induced by the oncogene ...
May 21, 2013
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Blood offers promise as a way to detect Alzheimer's disease at its earliest onset, Mayo Clinic researchers say. They envision a test that would detect distinct metabolic signatures in blood plasma that are synonymous with ...
May 29, 2013
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Beyond the personal tragedy of chronic alcoholism there is heartbreak in the biological sense, too. Scientists know severe alcoholism stresses the heart and that mitochondria, the cellular energy factories, are especially ...
Feb 23, 2012
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Predictive mathematical models of signalling pathways are powerful biological tools that could be used for drug development. Using a similar approach, European scientists developed a computational model for answering research ...
Aug 30, 2012
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