Researchers unravel molecular roots of Down syndrome
Sanford-Burnham researchers discover that the extra chromosome inherited in Down syndrome impairs learning and memory because it leads to low levels of SNX27 protein in the brain.
Medical research
Mar 24, 2013 |
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Extra chromosome 21 removed from Down syndrome cell line
(Medical Xpress)—University of Washington scientists have succeeded in removing the extra copy of chromosome 21 in cell cultures derived from a person with Down syndrome, a condition in which the body's ...
Medical research
Nov 09, 2012 |
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Baby's genome deciphered prenatally from parents' lab tests
Scientists have successfully sequenced the genome of a baby in the womb without tapping its protective fluid sac. This non-invasive approach to obtaining the fetal genome is reported in the June 6 issue of ...
Genetics
Jun 06, 2012 |
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Biologists use flies, mice to study Down syndrome
A novel study involving fruit flies and mice has allowed biologists to identify two critical genes responsible for congenital heart defects in individuals with Down syndrome, a major cause of infant mortality ...
Genetics
Nov 04, 2011 |
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Cholesterol increases risk of Alzheimer's and heart disease
Researchers at the Linda Crnic Institute for Down Syndrome and the University of Colorado School of Medicine have found that a single mechanism may underlie the damaging effect of cholesterol on the brain and on blood vessels.
Medical research
Apr 15, 2013 |
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New study documents women's experiences with chromosome abnormalities found in new prenatal test
(Medical Xpress)—We often hear that "knowledge is power." But, that isn't always the case, especially when the knowledge pertains to the health of an unborn child, with murky implications, at best. A new study, led by researchers ...
Genetics
Sep 21, 2012 |
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Understanding and treating the cognitive dysfunction of Down syndrome and Alzheimer's disease
Down syndrome (DS) is the most common genetic disorder in live born children arising as a consequence of a chromosomal abnormality. It occurs as a result of having three copies of chromosome 21, instead of the usual two. ...
Psychology & Psychiatry
Mar 01, 2012 |
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Fragile X and Down syndromes share signalling pathway for intellectual disability
Intellectual disability due to Fragile X and Down syndromes involves similar molecular pathways report researchers in The EMBO Journal. The two disorders share disturbances in the molecular events that regula ...
Genetics
Aug 03, 2012 |
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Down's syndrome testing hits several European markets
A new prenatal test for Down's syndrome hit the market in Germany and several other European countries Monday, the manufacturer said, amid a controversy over whether it could lead to more abortions.
Diseases, Conditions, Syndromes
Aug 20, 2012 |
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BPA alters development of in vitro ova and could increase risk of Down syndrome
Researchers at Universitat Autonoma de Barcelona analysed the effects of Bisphenol A (BPA), a polymer widely used to manufacture plastics, in an in vitro culture of ovaries. The research demonstrated that exposure to this ...
Health
Sep 21, 2011 |
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Study finds specific gene linked to cold sore susceptibility
Investigators have identified a human chromosome containing a specific gene associated with susceptibility to herpes simplex labialis (HSL), the common cold sore. Published in the Journal of Infectious Diseases and now av ...
Diseases, Conditions, Syndromes
Oct 28, 2011 |
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Prenatal intervention reduces learning deficit in mice
Mice with a condition that serves as a laboratory model for Down syndrome perform better on memory and learning tasks as adults if they were treated before birth with neuroprotective peptides, according to researchers at ...
Medical research
Nov 30, 2012 |
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Study offers insights into role of muscle weakness in Down syndrome
It is well known that people with Down syndrome (DS) suffer from marked muscle weakness. Even the simple tasks of independent living, such as getting out of a chair or climbing a flight of stairs, can become major obstacles. ...
Psychology & Psychiatry
Dec 17, 2012 |
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Test for chromosome abnormalities sheds light on genetic origins of faulty eggs
Researchers are developing a new way to test a woman's egg for chromosome abnormalities that avoids the need to manipulate and biopsy the egg itself. The research may also shed light on the crucial role played by certain ...
Medical research
Jul 05, 2011 |
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Could ovarian stimulation cause an increase in chromosome copy number abnormalities?
Ovarian stimulation undertaken by women of advanced maternal age receiving fertility treatment may be disrupting the normal pattern of meiosis -- a critical process of chromosome duplication followed by two specialized cell ...
Other
Jul 05, 2011 |
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