News tagged with clinical investigation
The X factor in liver metabolism
After you eat, your liver switches from producing glucose to storing it. At the same time, a cellular signaling pathway known as the unfolded protein response (UPR) is transiently activated, but it is not clear how this pathway ...
Medical research
Dec 21, 2012 |
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A new type of nerve cell found in the brain
Scientists at Karolinska Institutet in Sweden, in collaboration with colleagues in Germany and the Netherlands, have identified a previously unknown group of nerve cells in the brain. The nerve cells regulate ...
Neuroscience
Dec 21, 2012 |
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Researchers discover new pathways that drive metastatic prostate cancer
Elevated levels of Cyclin D1b could function as a novel biomarker of lethal metastatic disease in prostate cancer patients, according to a pre-clinical study published ahead of print on December 21 in the Journal of Clinical In ...
Cancer
Dec 21, 2012 |
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Hypertension traced to source in brain
(Medical Xpress)—When the heart works too hard, the brain may be to blame, says new Cornell research that is changing how scientists look at high blood pressure (hypertension). The study, published in the ...
Medical research
Dec 18, 2012 |
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Researchers discover new molecule linked to late-stage breast cancer
Researchers at Case Western Reserve University School of Medicine have identified a molecule linked to more aggressive forms of breast cancer – a discovery that could point the way to potential cures.
Cancer
Dec 17, 2012 |
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Harnessing the ID in glioma
Gliomas are the most common form of brain tumor. They are highly aggressive and effective treatments are not currently available. The tumors contain glioma initiating cells (GICs), a population that is highly similar to neural ...
Cancer
Dec 17, 2012 |
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Research identifies targeted molecular therapy for untreatable NF1 tumors
Researchers conducting a preclinical study in mice successfully used targeted molecular therapy to block mostly untreatable nerve tumors that develop in people with the genetic disorder Neurofibromatosis 1 (NF1).
Cancer
Dec 10, 2012 |
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Brown adipose tissue beneficial for metabolism and glucose tolerance
Joslin Diabetes Center scientists have demonstrated that brown adipose tissue (BAT) has beneficial effects on glucose tolerance, body weight and metabolism. The findings, which may lead to new treatments for diabetes, appear ...
Medical research
Dec 10, 2012 |
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Alzheimer's researcher reveals a protein's dual destructiveness—and therapeutic potential
A scientist at the University of British Columbia and Vancouver Coastal Health has identified the molecule that controls a scissor-like protein responsible for the production of plaques – the telltale sign of Alzheimer's ...
Alzheimer's disease & dementia
Dec 03, 2012 |
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Lithium restores cognitive function in Down syndrome mice
Down syndrome is a neurodevelopmental disorder that is the leading cause of genetically defined intellectual disability. In the brain, Down syndrome results in alterations in the connections between neurons and a reduction ...
Neuroscience
Dec 03, 2012 |
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Stem cell-derived dopaminergic neurons rescue motor defects in Parkinsonian monkeys
Parkinson's disease is a degenerative disorder of the central nervous system that is characterized by tremors, rigidity, slowness of movement, and difficulty walking. It is caused by loss of the neurons that produce the neurotransmitter ...
Parkinson's & Movement disorders
Dec 03, 2012 |
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Bariatric surgical procedures have similar therapeutic benefits in obese adults
Obesity is associated with insulin resistance and type 2 diabetes, both of which can be significantly improved by weight loss. Gastric bypass and adjustable gastric banding are two bariatric surgery techniques that are frequently ...
Surgery
Nov 26, 2012 |
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Drugs limiting excess mucus could save lives
Respiratory conditions that restrict breathing such as asthma and chronic obstructive pulmonary disease (COPD) are common killers worldwide. But no effective treatments exist to address the major cause of ...
Diseases, Conditions, Syndromes
Nov 26, 2012 |
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Seizures linked to surgery drugs can be prevented by anesthetics, study finds (Update)
Two drugs commonly given during cardiac surgery can lead to convulsive seizures, but anesthetics can help cut the risk, according to new research from the Faculty of Medicine at the University of Toronto.
Neuroscience
Nov 26, 2012 |
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Pathway identified in human lymphoma points way to new blood cancer treatments
A pathway called the "Unfolded Protein Response," or UPR, a cell's way of responding to unfolded and misfolded proteins, helps tumor cells escape programmed cell death during the development of lymphoma.
Cancer
Nov 21, 2012 |
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