In a first-ever human clinical trial of four adult patients, an mRNA cancer vaccine developed at the University of Florida quickly reprogrammed the immune system to attack glioblastoma, the most aggressive and lethal brain ...
May 1, 2024
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357
Inulin, a type of fiber found in certain plant-based foods and fiber supplements, causes inflammation in the gut and exacerbates inflammatory bowel disease in a preclinical model, according to a new study by Weill Cornell ...
May 3, 2024
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161
New research from the University of Georgia suggests that something as simple as a cup of tea can help in the fight against COVID-19.
Apr 8, 2024
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640
In a paper titled, "Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness," published in Science Translational Medicine, a group of researchers at Massachusetts General Hospital and ...
May 1, 2024
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Researchers from the Brigham and colleagues report on the long-term follow-up of the largest study of women's health in the U.S., shedding light on the role of menopausal hormone therapy, calcium and vitamin D supplementation, ...
May 1, 2024
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17
A combination of two antiviral compounds may be a promising alternative to Paxlovid when treating COVID-19 in immunocompromised patients, according to Karen S. Anderson, Ph.D., professor of pharmacology and of molecular biophysics ...
Apr 30, 2024
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Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer's disease ...
Apr 5, 2024
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51
Researchers have used artificial intelligence techniques to massively accelerate the search for Parkinson's disease treatments.
Apr 17, 2024
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77
Melanoma is the deadliest form of skin cancer. With global incidence rates rising, new, more effective treatments are necessary to alleviate the health burden of the disease. Important advances in recent years include doctors ...
Apr 12, 2024
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87
Psilocybin—the active ingredient in "magic" mushrooms—is a more effective treatment for symptoms of depression than controls, providing further support for its potential as an antidepressant, suggests a study published ...
May 1, 2024
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In clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices. These trials can only take place once satisfactory information has been gathered on the quality of the product and its non-clinical safety, and Health Authority/Ethics Committee approval is granted in the country where the trial is taking place.
Depending on the type of product and the stage of its development, investigators enroll healthy volunteers and/or patients into small pilot studies initially, followed by larger scale studies in patients that often compare the new product with the currently prescribed treatment. As positive safety and efficacy data are gathered, the number of patients is typically increased. Clinical trials can vary in size from a single center in one country to multicenter trials in multiple countries.
Due to the sizable cost a full series of clinical trials may incur, the burden of paying for all the necessary people and services is usually borne by the sponsor who may be the pharmaceutical or biotechnology company that developed the agent under study. Since the diversity of roles may exceed resources of the sponsor, often a clinical trial is managed by an outsourced partner such as a contract research organization
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