People who have reduced enzyme activity to breakdown active aldehyde, i.e., those who become easily inebriated, are more likely to develop fatty liver disease even if they do not drink alcohol. This discovery was made by ...
May 24, 2016
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How much alcohol you drink and how hard it affects you are rooted in your DNA. Much studied in Asian populations, this study at the University of Valencia contributes conclusive evidence to an emerging Western scientific ...
Jan 20, 2016
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Researchers at the University at Buffalo, led by Dr. Mulchand Patel and also at Lawson Health Research Institute and Western Ontario, London, Canada, led by Dr. David Hill, collaboratively evaluated the role of the mitochondrial ...
Aug 5, 2014
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Agios Pharmaceuticals announced today the publication of two articles in the journal Science by Agios scientists and their collaborators demonstrating the effects of the company's small molecule isocitrate dehydrogenase 1 ...
Apr 4, 2013
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In malaria-endemic countries, 350 million people are predicted to be deficient in an enzyme that means they can suffer severe complications from taking primaquine, a key drug for treating relapsing malaria, according to a ...
Nov 13, 2012
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Cleveland Clinic researchers have discovered that vitamin E may prevent cancer in patients with an under-recognized genetic disorder.
Sep 17, 2012
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Researchers at Winship Cancer Institute have developed a technique for detecting an "oncometabolite", a chemical produced by some brain tumors' warped metabolism, via non-invasive imaging.
Mar 22, 2012
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Researchers used gene transfer to block the expression of one of the two main enzymes that break down alcohol in the liver, leading to the accumulation in liver cells of acetaldehyde, a metabolic byproduct of ethanol. The ...
Sep 18, 2017
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In cardiac hypertrophy, metabolic energy reserves in the heart are depleted, which is thought to contribute to the subsequent development of heart failure. The primary energy source in the heart relies on fatty acid oxidation ...
Feb 25, 2016
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Patterns of alcohol use that begin during adolescence are important factors in the development of alcohol use disorders (AUDs) during adulthood. While researchers know that adolescent drinking is influenced by both genetic ...
Sep 23, 2014
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