Epigenetic changes shed light on biological mechanism of autism
Scientists from King's College London have identified patterns of epigenetic changes involved in autism spectrum disorder (ASD) by studying genetically identical twins who differ in autism traits. The study, published in ...
Autism spectrum disorders
Apr 23, 2013 |
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Particular DNA changes linked with prostate cancer development and lethality
A new analysis has found that the loss or amplification of particular DNA regions contributes to the development of prostate cancer, and that patients with two of these DNA changes have a high likelihood of dying from the ...
Cancer
Apr 22, 2013 |
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Researchers abuzz over caffeine as cancer-cell killer
(Medical Xpress)—Researchers from the University of Alberta are abuzz after using fruit flies to find new ways of taking advantage of caffeine's lethal effects on cancer cells—results that could one day ...
Cancer
Apr 18, 2013 |
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Autism linked to increased genetic change in regions of genome instability
(Medical Xpress)—Children with autism have increased levels of genetic change in regions of the genome prone to DNA rearrangements, so called "hotspots," according to a research discovery to be published ...
Autism spectrum disorders
Apr 03, 2013 |
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Pathologists identify patterns of mutations to help inform design of future trials
Molecular driven therapeutic targets have resulted in a paradigm shift in the treatment of advanced lung adenocarcinoma. However, in early non-small cell lung cancer (NSCLC), surgical resection remains the treatment of choice ...
Cancer
Mar 22, 2013 |
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Researchers link cancer to failures in chromosome protection for the first time
A study published today in the journal Nature Genetics explores a new mechanism that may contribute to the development of several tumours, including Chronic Lymphocytic Leukaemia, a type of cancer that affects more than a ...
Genetics
Mar 19, 2013 |
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New clues in hunt for heredity in type 2 diabetes
Type 2 diabetes has strong hereditary tendencies and the genes we are born with cannot be changed. However, new research from Lund University in Sweden shows that we can modify the function of the genes through the epigenetic ...
Genetics
Mar 19, 2013 |
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Epigenetic changes play a key role in development of chemo resistance in BCa
At the 28th Annual EAU Congress currently ongoing in Milan until Tuesday, W. Tan and colleagues presented their study on neoadjuvant cisplatin-based chemotherapy which showed that epigenetic changes are potential key drivers ...
Cancer
Mar 18, 2013 |
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Two studies reveal genetic variation driving human evolution
A pair of studies published by Cell Press on February 14th in the journal Cell sheds new light on genetic variation that may have played a key role in human evolution. The study researchers used an animal ...
Genetics
Feb 14, 2013 |
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Novel microscale epigenomics technology: Possible to study the epigenome of rare cell populations and biopsy samples
Scientists at A*STAR's Genome Institute of Singapore (GIS) have successfully developed a method to map the epigenome using 100 times fewer cells than was previously possible. The discovery, published in the journal Developmental Ce ...
Genetics
Feb 11, 2013 |
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Personal epigenetic 'signatures' found consistent in prostate cancer patients' metastases
In a genome-wide analysis of 13 metastatic prostate cancers, scientists at the Johns Hopkins Kimmel Cancer Center found consistent epigenetic "signatures" across all metastatic tumors in each patient. The discovery of the ...
Cancer
Jan 23, 2013 |
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Novel gene-searching software improves accuracy in disease studies
A novel software tool, developed at The Children's Hospital of Philadelphia, streamlines the detection of disease-causing genetic changes through more sensitive detection methods and by automatically correcting for variations ...
Genetics
Jan 22, 2013 |
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Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma
Think of the epigenome like a giant musical mixing board, turning up or down the expression of various genes. A University of Colorado Cancer Center study published today in the journal PLOS Genetics shows that in cancer ...
Genetics
Jan 10, 2013 |
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Scientists use Pap test fluid to detect ovarian, endometrial cancers
Using cervical fluid obtained during routine Pap tests, scientists at the Johns Hopkins Kimmel Cancer Center have developed a test to detect ovarian and endometrial cancers. In a pilot study, the "PapGene" test, which relies ...
Cancer
Jan 09, 2013 |
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Search for epigenetic decoder leads scientists to Rett Syndrome
(Medical Xpress)—A few years ago, scientists discovered an unexpected layer of information woven into the genetic code – a nucleotide called 5-hydroxymethylcytosine, or 5hmC. Its meaning was unknown at the time, but a ...
Medical research
Dec 21, 2012 |
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