Genetics
Research on mutation 'hotspots' in DNA could lead to new insights on cancer risks
New research from Indiana University has identified "hotspots" in DNA where the risk for genetic mutations is significantly elevated.
Jul 30, 2018
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News tagged with dna mismatch repair
Oncology & Cancer
New insights into the origins of mutations in cancer
Researchers at the European Bioinformatics Institute (EMBL-EBI), the University of Dundee and the Wellcome Sanger Institute have used human and worm data to explore the mutational causes of cancer. Their study, published ...
May 1, 2018
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Genetics
Cells rank genes by importance to protect them, according to new research
Researchers at the University of Oxford have discovered that a cellular mechanism preferentially protects plant genes from the damaging effects of mutation.
Jan 5, 2018
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Genetics
DNA correction mechanism is more efficient in the most important regions of the genome
A study published by IRB Barcelona in Nature Genetics demonstrates that the error (mutation) surveillance and repair system shows greater efficiency in the protein-coding regions of genes.
Nov 7, 2017
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Oncology & Cancer
Biomarkers for identifying tumor aggressiveness
Early-stage colon cancer patients could benefit in the future from specific genetic tests that forecast their prognosis and help them make the right decision regarding chemotherapy. Two of the biomarkers involved are the ...
Jul 26, 2017
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Oncology & Cancer
FDA approves cancer drug for personalized immunotherapy approach
Earlier this week, for the first time, a drug was FDA-approved for cancer based on disease genetics rather than type.
May 26, 2017
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Oncology & Cancer
A counterintuitive finding that could benefit younger colorectal cancer patients
Younger colon cancer patients appear to have more than three times as many mutations in their tumors as older patients, which could lead to more effective treatment decisions, say researchers at Georgetown Lombardi Comprehensive ...
May 17, 2017
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Genetics
Selective protection of genetic information by epigenetic system
DNA is replicated to pass genetic information to the daughter cells during cell proliferation. Replication errors, if not repaired, can lead to genetic mutations. For an individual organism, some DNA mutations may cause disease, ...
Aug 29, 2016
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Oncology & Cancer
Genetic cause of 15 percent of colorectal cancer diagnoses identified
Up to 15 percent of colorectal cancers show a genetic mutation known as DNA mismatch repair deficiency, or dMMR. Until now, little has been known about how the mutation behaves in rectal cancer patients, what causes dMMR, ...
Jul 19, 2016
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Oncology & Cancer
Researchers report breakthrough inhibition of colon tumors in mice models
Scientists from the Institute for Basic Science (IBS) have successfully inhibited the growth of colon tumors in mice with mismatch repair deficiency. The research team, headed by the Center's director MYUNG Kyungjae, made ...
Jun 15, 2016
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