The brain is the most protected organ in the body, sheathed in a complex and nearly impenetrable barrier of specialized blood vessels. While this particular anatomical setup protects it from outside invaders, it also makes ...
Jan 10, 2024
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Driven by the need for a better way to prioritize targets for drug development, the Icahn School of Medicine at Mount Sinai has led the development of a novel "genetic priority score" (GPS) that will integrate various types ...
Jan 3, 2024
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A study led by VA Connecticut Healthcare Center/Yale researchers reveals ancestries around the world possess a shared genetic architecture for problematic alcohol use (PAU)—habitual heavy drinking, accompanied by harmful ...
Dec 22, 2023
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Researchers at the Center for Genomic Regulation in Barcelona, Spain, and the Wellcome Sanger Institute near Cambridge, UK, have comprehensively identified the allosteric control sites found in the protein KRAS. These are ...
Dec 18, 2023
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Drug development for lung diseases is complicated. Most clinical trials that test novel drugs fail due to the fact that laboratory models cannot accurately replicate human physiology.
Dec 6, 2023
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Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists—so far. A new multi-chamber organoid that mirrors the heart's ...
Nov 28, 2023
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Researchers at Cleveland Clinic have identified a new way that the SARS-CoV-2 virus hijacks its host's translation machinery using elements within its genetic material and causes COVID-19, paving the way for future study.
Nov 14, 2023
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Neurons talk to each other using chemical signals called neurotransmitters. Scientists at St. Jude Children's Research Hospital have drawn on structural biology expertise to determine structures of vesicular monoamine transporter ...
Nov 1, 2023
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An enzyme that may help some breast cancers spread can be stopped with an antibody created in the lab of Cold Spring Harbor Laboratory Professor Nicholas Tonks. With further development, the antibody might offer an effective ...
Oct 30, 2023
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Researchers at Nagoya University in Japan have created and improved artificial intelligence (AI) designs to synthesize a candidate compound for a new gastric acid inhibitor with a better binding affinity than existing drugs. ...
Oct 27, 2023
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