News tagged with embryonic stem cells
The first use of embryonic stem cells in humans eased a degenerative form of blindness in two volunteers and showed no signs of any adverse effects, according to a study published by The Lancet on Monday.
Medical research Jan 23, 2012 | 4.7 / 5 (15) | 0
Johns Hopkins scientists have developed a reliable method to turn the clock back on blood cells, restoring them to a primitive stem cell state from which they can then develop into any other type of cell in the body.
Medical research Aug 22, 2012 | 4.7 / 5 (13) | 2 |
Among the many hurdles to be cleared before human embryonic stem cells can achieve their therapeutic potential is determining whether or not transplanted cells can functionally integrate into target organs or tissues.
Neuroscience Nov 21, 2011 | 4.9 / 5 (10) | 0 |
Researchers at Johns Hopkins have identified a gene that, when repressed in tumor cells, puts a halt to cell growth and a range of processes needed for tumors to enlarge and spread to distant sites. The researchers hope that ...
Cancer May 02, 2013 | 4.7 / 5 (10) | 0 |
A retrovirus called HERV-H, which inserted itself into the human genome millions of years ago, may play an important role in pluripotent stem cells, according to a new study published in the journal Retrovirology by scient ...
Medical research Jan 23, 2013 | 5 / 5 (9) | 2 |
For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, with limited success. The "reprogramming" of related alpha cells into beta cells ...
Medical research Feb 22, 2013 | 4.5 / 5 (8) | 0 |
Deep inside your brain, a legion of stem cells lies ready to turn into new brain and nerve cells whenever and wherever you need them most. While they wait, they keep themselves in a state of perpetual readiness ...
Neuroscience Apr 10, 2013 | 5 / 5 (7) | 0 |
For the first time ever, stem cells from umbilical cords have been converted into other types of cells, which may eventually lead to new treatment options for spinal cord injuries and multiple sclerosis, among other nervous ...
Neuroscience Jan 17, 2012 | 4.6 / 5 (7) | 0 |
(Medical Xpress) -- A new study published in Nature reports that scientists have been able to grow working pituitary glands from embryonic stem cells from mice. When these were transplanted into mice with defects in the pi ...
Medical research Nov 10, 2011 | 5 / 5 (6) | 1 |
For the first time, human embryonic stem cells have been transformed into nerve cells that helped mice regain the ability to learn and remember. A study at the University of Wisconsin-Madison is the first ...
Medical research Apr 21, 2013 | 4.3 / 5 (7) | 6 |
In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed "super-enhancers" that control cell state ...
Cancer Apr 11, 2013 | 4.8 / 5 (6) | 0 |
A new study by scientists at King's College London and the University of Arizona (UA) published in Science reveals the deep similarities in how the brain regulates behaviour in arthropods (such as flies ...
Neuroscience Apr 11, 2013 | 4.8 / 5 (6) | 1 |
Johns Hopkins researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.
Medical research May 11, 2011 | 4.3 / 5 (6) | 2 |
A study led by researchers at the UC San Diego Stem Cell Research program and funded by the California Institute for Regenerative Medicine (CIRM) looks at an important RNA binding protein called LIN28, which ...
Genetics Sep 04, 2012 | 4.3 / 5 (6) | 0 |
For the first time, researchers at Brigham and Women's Hospital (BWH) have identified a human lung stem cell that is self-renewing and capable of forming and integrating multiple biological structures of the lung including ...
Medical research May 11, 2011 | 5 / 5 (5) | 0 |
Embryonic stem cell
Embryonic stem cells (ES cells) are stem cells derived from the inner cell mass of an early stage embryo known as a blastocyst. Human embryos reach the blastocyst stage 4–5 days post fertilization, at which time they consist of 50–150 cells.
Embryonic Stem (ES) cells are pluripotent. This means they are able to differentiate into all derivatives of the three primary germ layers: ectoderm, endoderm, and mesoderm. These include each of the more than 220 cell types in the adult body. Pluripotency distinguishes ES cells from multipotent progenitor cells found in the adult; these only form a limited number of cell types. When given no stimuli for differentiation, (i.e. when grown in vitro), ES cells maintain pluripotency through multiple cell divisions. The presence of pluripotent adult stem cells remains a subject of scientific debate; however, research has demonstrated that pluripotent stem cells can be directly generated from adult fibroblast cultures.
Because of their plasticity and potentially unlimited capacity for self-renewal, ES cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. However Diseases treated by these non-embryonic stem cells include a number of blood and immune-system related genetic diseases, cancers, and disorders; juvenile diabetes; Parkinson's; blindness and spinal cord injuries. Besides the ethical concerns of stem cell therapy (see stem cell controversy), there is a technical problem of graft-versus-host disease associated with allogeneic stem cell transplantation. However, these problems associated with histocompatibility may be solved using autologous donor adult stem cells or via therapeutic cloning.
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