Dentistry

Study reveals how too much fluoride causes defects in tooth enamel

Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel—a novel explanation for how dental fluorosis, a condition caused by overexposure ...

Neuroscience

The ever-changing brain: Shining a light on synaptic plasticity

Synapses allow neurons to communicate with one another. In the synapse, one neuron emits chemical messengers called neurotransmitters, and an adjacent neuron receives them using tiny structures called receptors. A specific ...

Medical research

Scientists delineate pathway that helps us make antibodies

Our bodies are continuously concocting specific antibodies to thwart invaders like a virus or even pollen, and scientists have new information about how the essential production gets fired up and keeps up.

Medical research

Researchers solve mystery surrounding a form of Batten disease

A team led by researchers at Baylor College of Medicine has uncovered an unexpected mechanism that can explain a form of Batten disease called neuronal ceroid lipofuscinosis 8. The findings published in the journal Nature ...

Genetics

Potential drug targets for ALS revealed in study using CRISPR

In a new application of gene-editing technology, researchers at the Stanford University School of Medicine have gleaned insights into the genetic underpinnings of amyotrophic lateral sclerosis, a neurodegenerative disease ...

Medical research

A 12-hour biological clock coordinates essential bodily functions

Some bodily activities, sleeping, for instance, mostly occur once every 24 hours; they follow a circadian rhythm. Other bodily functions, such as body temperature, cognitive performance and blood pressure, present an additional ...

Neuroscience

Scientists develop new drug screening tool for dystonia

Duke University researchers have identified a common mechanism underlying separate forms of dystonia, a family of brain disorders that cause involuntary, debilitating and often painful movements, including twists and turns ...

Parkinson's & Movement disorders

New findings challenge current view on origins of Parkinson's disease

The neurodegeneration that occurs in Parkinson's disease is a result of stress on the endoplasmic reticulum in the cell rather than failure of the mitochondria as previously thought, according to a study in fruit flies. It ...

Neuroscience

Turn left! How myosin-Va helps direct neuron growth

Researchers at the RIKEN Brain Science Institute in Japan have discovered a protein complex that helps direct the growth of axons—the parts of neurons that make up our nerves, connecting our senses and muscles to the brain ...

Immunology

Study reveals how herpes virus tricks the immune system

With over half the U.S. population infected, most people are familiar with the pesky cold sore outbreaks caused by the herpes virus. The virus outsmarts the immune system by interfering with the process that normally allows ...

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