Oncology & Cancer
Natural killers: Using the body's cells to target breast cancer
It sounds like a plot from a Quentin Tarantino movie—something sets off natural killers and sends them on a killing spree.
Jun 16, 2021
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News tagged with fusion proteins
Medical research
Novel structure found in tumor cells may open door to new kinds of cancer therapies
In 2015, researchers at UC San Francisco found a structure inside of tumor cells that biologists had never seen before. Even more surprising, a closer examination of the structure revealed that it contained signaling proteins known ...
May 12, 2021
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Oncology & Cancer
Scientists identify potential drug candidates for deadly pediatric leukemia
Scientists have shown that two existing drug candidates—JAK inhibitors and Mepron—hold potential as treatments for a deadly acute myeloid leukemia (AML) subtype that is more common in children.
Apr 14, 2021
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Oncology & Cancer
Rare but important gene target found in many tumor types, suggesting new therapy possible
A consortium of researchers led by Georgetown Lombardi Comprehensive Cancer Center investigators have completed the largest analysis of a new gene fusion they believe is responsible for development of a wide spectrum of cancer ...
Apr 15, 2019
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Immunology
White blood cells in different subsets have varying propensities to fuse in response to inflammation
White blood cells, also known as monocytes, play a key role in the immune system's response to infection. They have been shown to fuse and form multinucleated giant cells (MGCs) during inflammatory reactions, or in response ...
Jan 15, 2019
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Immunology
Specially designed protein fights several species of bacteria
As resistance to existing antibiotics increases, new approaches to serious bacterial infections are needed. Now researchers at Lund University in Sweden, together with colleagues at the University of Massachusetts Medical ...
Dec 13, 2017
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Surgery
Study cautions against use of bone morphogenetic proteins in children's spine surgery
Bone morphogenetic proteins, commonly used off-label to enhance pediatric spinal fusion (spinal arthrodesis), did not improve revision rates for pediatric spinal fusion, according to a study presented on March 14 at the American ...
Mar 14, 2017
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Medical research
Possible strategy identified for Charcot-Marie-Tooth disease, other disorders
Charcot-Marie-Tooth disease is an inherited disorder that leads to a gradual loss of motor neurons and, eventually, paralysis. The condition is caused by genetic mutations that disrupts cells' energy factories, called mitochondria. ...
Oct 24, 2016
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Oncology & Cancer
Childhood cancer hijacks cellular quality control system to fuel growth
A serious childhood cancer takes advantage of a quality control mechanism that usually protects cells from stress-induced damage to propel tumor growth, according to a new study led by researchers at UC San Francisco and ...
Jul 20, 2016
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Medical research
A rational drug engineering approach could breathe new life into drug development
A new strategy for engineering protein fusions—to make specific cell-targeted drugs without side effects—could enable a safer, more potent class of protein drugs. A team at the Wyss Institute for Biologically Inspired ...
Apr 25, 2016
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