Mapping the embryonic epigenome
A large, multi-institutional research team involved in the NIH Epigenome Roadmap Project has published a sweeping analysis in the current issue of the journal Cell of how genes are turned on and off to direct early human ...
Genetics
May 09, 2013 |
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Firefly protein lights up degenerating muscles, aiding muscular-dystrophy research
Stanford University School of Medicine scientists have created a mouse model of muscular dystrophy in which degenerating muscle tissue gives off visible light. The observed luminescence occurs only in damaged muscle tissue ...
Medical research
Apr 24, 2013 |
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Scientists find ethnicity linked to antibodies
(Medical Xpress)—Cracking the DNA code for a complex region of the human genome has helped 14 North American scientists, including five at Simon Fraser University, chart new territory in immunity research.
Genetics
Apr 17, 2013 |
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Same gene variant promotes pain in women, suppresses pain in men
More women than men develop chronic low back pain and sciatica. The explanation may lie with a gene variant that plays into the body's pain regulation.
Medical research
Apr 12, 2013 |
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Researchers identify gene variations that predict chemotherapy side effects
Seemingly benign differences in genetic code from one person to the next could influence who develops side effects to chemotherapy, a Mayo Clinic study has found. The study identified gene variations that can predispose people ...
Cancer
Apr 09, 2013 |
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New insights into how genes turn on and off
Researchers at UC Davis and the University of British Columbia have shed new light on methylation, a critical process that helps control how genes are expressed. Working with placentas, the team discovered that 37 percent ...
Genetics
Mar 27, 2013 |
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Study finds molecular 'signature' for rapidly increasing form of esophageal cancer
During the past 30 years, the number of patients with cancers that originate near the junction of the esophagus and stomach has increased approximately 600 percent in the United States. The first extensive probe of the DNA ...
Cancer
Mar 24, 2013 |
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Why a hereditary anemia is caused by genetic mutation in mechanically sensitive ion channel
A genetic mutation that alters the kinetics of an ion channel in red blood cells has been identified as the cause behind a hereditary anemia, according to a paper published this month in the Proceedings of the National Ac ...
Medical research
Mar 08, 2013 |
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Paternal obesity impacts child's chances of cancer
A father's obesity is one factor that may influence his children's health and potentially raise their risk for diseases like cancer, according to new research from Duke Medicine.
Overweight and Obesity
Feb 05, 2013 |
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Gene variants found to affect human lifespan
By broadly comparing the DNA of children to that of elderly people, gene researchers have identified gene variants that influence lifespan, either by raising disease risk or by providing protection from disease.
Genetics
Feb 04, 2013 |
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Epigenetic marker 5hmC opens door to studying its role in developmental disorders and disease
Nearly every cell in the human body carries a copy of the full human genome. So how is it that the cells that detect light in the human eye are so different from those of, say, the beating heart or the spleen?
Genetics
Feb 04, 2013 |
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New mutations driving malignant melanoma discovered
Two new mutations that collectively occur in 71 percent of malignant melanoma tumors have been discovered in what scientists call the "dark matter" of the cancer genome, where cancer-related mutations haven't ...
Cancer
Jan 24, 2013 |
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Targeting hepatitis C treatment: The importance of interleukin (IL)-28
A metanalysis published in BioMed Central's open access journal BMC Medicine has confirmed that polymorphisms (SNP) in the gene coding for interleukin-28 (IL28B) influence natural hepatitis C viral (HCV) ...
Diseases, Conditions, Syndromes
Jan 07, 2013 |
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Chromatin marks the spot in search for disease pathways
In September 2012, the Encyclopedia of DNA Elements (ENCODE) Project Consortium, a multi-institution collaboration that included the Broad Institute, capped off nine years of research with a flurry of papers ...
Genetics
Jan 07, 2013 |
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Search for epigenetic decoder leads scientists to Rett Syndrome
(Medical Xpress)—A few years ago, scientists discovered an unexpected layer of information woven into the genetic code – a nucleotide called 5-hydroxymethylcytosine, or 5hmC. Its meaning was unknown at the time, but a ...
Medical research
Dec 21, 2012 |
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