After several decades of pre-clinical development, cell- and gene-based therapies for Parkinson's disease (PD) are now actively being explored. In this special supplement to the Journal of Parkinson's Disease, "Repairing ...
Sep 24, 2021
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Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances ...
Sep 21, 2021
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KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common drivers of cancer and its mutations can be detected in around 25 percent of human tumors. The development of KRAS inhibitors ...
Jul 19, 2021
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Monash University researchers have uncovered for the first time the reason mutations in a particular gene lead to mitochondrial disease.
Apr 27, 2021
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Gut hormones play an important role in regulating fat production in the body. One key hormone, released a few hours after eating, turns off fat production by regulating gene expression in the liver, but this regulation is ...
Nov 24, 2020
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Greenwood Genetic Center (GGC) researchers, in collaboration with scientists from Belgium, Spain, and Italy, have confirmed that variants in LMNB1 cause syndromic microcephaly with variable short stature, intellectual disability, ...
Sep 17, 2020
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Acute myeloid leukemia (AML) is one of the most common forms of blood cancer among adults and is associated with a low survival rate, and leads to the inhibition of normal blood formation. Now, a research team at Lund University ...
Jun 3, 2020
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The Parkin gene protects nerve cells against functional impairment and cell death. It particularly ensures that mitochondria, cell organelles that are responsible for energy production, remain intact and that damaged mitochondria ...
Feb 5, 2020
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Researchers have discovered changes in blood samples associated with Alzheimer's disease. A new international study examined disease-discordant twin pairs: one sibling who suffered from Alzheimer's disease and one who was ...
Oct 14, 2019
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When considering the role of the key immune molecule interleukin (IL)-17, the phrase "too much of a good thing" springs to mind. Because unlike some of its more sedate cytokine cousins which studiously direct the immune response ...
Jun 3, 2019
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