Diseases, Conditions, Syndromes
Clinical histone deacetylase inhibitors are effective against COVID-19
COVID-19, caused by the SARS-CoV-2 virus, has posed serious health threats to humanity and jeopardized the global economy.
Dec 14, 2020
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News tagged with hdac
Medical research
Why some cancers may respond poorly to key drugs discovered
Patients with BRCA1/2 mutations are at higher risk for breast, ovarian and prostate cancers that can be aggressive when they develop—and, in many cases, resistant to lifesaving drugs. Now scientists at The University of ...
Sep 22, 2020
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Medical research
Scientists uncover a novel approach to treating Duchenne muscular dystrophy
Scientists at Sanford Burnham Prebys Medical Discovery Institute, Fondazione Santa Lucia IRCCS, and Università Cattolica del Sacro Cuore in Rome have shown that pharmacological (drug) correction of the content of extracellular ...
Sep 15, 2020
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Oncology & Cancer
HDAC6 can control tumor growth and halt metastasis in triple-negative breast cancer
Genetic modifier HDAC6 was found to control tumor growth and halt metastasis in triple-negative breast cancer in vivo, according to a new study published in the top-tier journal Cancer Research by investigators at the George ...
Aug 6, 2020
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Medical research
Researchers identify mechanisms that make skin a protective barrier
A Mount Sinai research team has identified one of the mechanisms that establish the skin as a protective barrier, a breakthrough that is critical to understanding and treating common skin conditions including eczema and psoriasis, ...
May 28, 2020
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Genetics
A deep dive into cellular aging
Scientists at Sanford Burnham Prebys Medical Discovery Institute and Harvard University have discovered that mitochondria trigger senescence, the sleep-like state of aged cells, through communication with the cell's nucleus—and ...
Feb 20, 2020
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Medications
Combining neurologic and blood pressure drugs reduces breast tumor development in mice
Adding a medication used to treat epilepsy, bipolar disorder and migraines to a blood pressure medicine reversed some aspects of breast cancer in the offspring of mice at high risk of the disease because of the high fat diet ...
Dec 30, 2019
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Medications
New drug combination shows promising activity in non-small cell lung cancer patients
Patients with non-small cell lung cancer (NSCLC) now have more improved treatment options compared to standard of care with the addition of several new agents called immune-checkpoint inhibitors (ICI). Despite these changes, ...
Aug 27, 2019
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Oncology & Cancer
Researchers identify effective drug combination against uveal melanoma
Uveal melanoma is a very aggressive type of melanoma that affects the eye. It is a rare disorder, affecting an estimated 2,500 people in the United States each year. However, nearly half of uveal melanoma patients will develop ...
Jul 8, 2019
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Oncology & Cancer
Immunotherapy and HDAC inhibition are anti-cancer besties
Immunotherapies have revolutionized the care of many cancers, teaching the body's own immune cells to recognize and attack tumor cells. Leading the way are drugs known as checkpoint inhibitors, which block a kind of "white ...
Jun 24, 2019
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