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Cancer drug prevents build-up of toxic brain protein

Researchers at Georgetown University Medical Center have used tiny doses of a leukemia drug to halt accumulation of toxic proteins linked to Parkinson's disease in the brains of mice. This finding provides the basis to plan ...

Genetics created May 10, 2013 | popularity 5 / 5 (3) | comments 0 | with audio podcast

New structural insight into neurodegenerative disease

A research team from the Korea Advanced Institute of Science and Technology (KAIST) released their results on the structure and molecular details of the neurodegenerative disease-associated protein Ataxin-1. ...

Genetics created Mar 14, 2013 | popularity 5 / 5 (2) | comments 0

Researchers find controlling element of Huntington's disease

A three molecule complex may be a target for treating Huntington's disease, a genetic disorder affecting the brain. This finding by an international research team including scientists from the German Center for Neurodegenerative ...

Diseases, Conditions, Syndromes created Feb 26, 2013 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Scientists identify molecular system that could help develop potential treatments for neurodegenerative diseases

Scientists from the University of Southampton have identified the molecular system that contributes to the harmful inflammatory reaction in the brain during neurodegenerative diseases.

Neuroscience created Feb 21, 2013 | popularity not rated yet | comments 0

Novel test streamlines testing for Huntington Disease

A new test may help to streamline genetic testing for Huntington Disease (HD) by generating accurate results, avoiding unnecessary additional testing, and improving turnaround time. The test, which uses chimeric or triplet ...

Genetics created Feb 13, 2013 | popularity not rated yet | comments 0 | with audio podcast

Immune cell migration is impeded in Huntington's disease

Huntington disease (HD) is an incurable neurodegenerative disease caused by a mutation in the huntingtin gene (htt). Though most of the symptoms of HD are neurological, the mutant HTT protein is expressed in non-neural cells ...

Diseases, Conditions, Syndromes created Nov 19, 2012 | popularity 5 / 5 (1) | comments 0

Latrepirdine not effective in Huntington's disease

(HealthDay)—Although safe and well tolerated, the experimental small molecule latrepirdine does not improve cognition after six months of treatment in patients with mild-to-moderate Huntington's disease ...

Neuroscience created Nov 01, 2012 | popularity not rated yet | comments 0

Making sense out of the biological matrix of bipolar disorder

The more that we understand the brain, the more complex it becomes. The same can be said about the genetics and neurobiology of psychiatric disorders. For "Mendelian" disorders, like Huntington disease, mutation of a single ...

Psychology & Psychiatry created Aug 20, 2012 | popularity not rated yet | comments 0

AAN: New guideline on how to best treat involuntary movements in Huntington's disease

A new guideline released by the American Academy of Neurology recommends several treatments for people with Huntington's disease who experience chorea—jerky, random, uncontrollable movements that can make everyday activities ...

Neuroscience created Jul 18, 2012 | popularity not rated yet | comments 0

Two proteins offer a 'clearer' way to treat Huntington's disease

In a paper published in the July 11 online issue of Science Translational Medicine, researchers at the University of California, San Diego School of Medicine have identified two key regulatory proteins critic ...

Neuroscience created Jul 11, 2012 | popularity 4.8 / 5 (4) | comments 0 | with audio podcast

Speeding up Huntington's research

(Medical Xpress) -- Human brain cells showing aspects of Huntington’s Disease have been developed, opening up new research pathways for treating the fatal disorder.

Neuroscience created Jul 09, 2012 | popularity 5 / 5 (1) | comments 0

Scientists correct Huntington's disease mutation in induced pluripotent stem cells

Johns Hopkins researchers, working with an international consortium, say they have generated stem cells from skin cells from a person with a severe, early-onset form of Huntington's disease (HD), and turned them into neurons ...

Medical research created Jun 28, 2012 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Proposed drug may reverse Huntington's disease symptoms

With a single drug treatment, researchers at the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine can silence the mutated gene responsible for Huntington's ...

Neuroscience created Jun 20, 2012 | popularity not rated yet | comments 0 | with audio podcast

Coenzyme Q10 study indicates promise in Huntington's treatment

A new study shows that the compound Coenzyme Q10 (CoQ) reduces oxidative damage, a key finding that hints at its potential to slow the progression of Huntington disease. The discovery, which appears in the inaugural issue ...

Neuroscience created Jun 18, 2012 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Device implanted in brain has therapeutic potential for Huntington's disease

Studies suggest that neurotrophic factors, which play a role in the development and survival of neurons, have significant therapeutic and restorative potential for neurologic diseases such as Huntington's ...

Neuroscience created Jun 18, 2012 | popularity not rated yet | comments 0 | with audio podcast