Researchers at Massachusetts General Hospital (MGH) have discovered that the interferon gamma receptor (IFNgR) signaling pathway is critical for susceptibility of glioblastoma tumors to killing by CAR T-cell immunotherapy. ...
Jun 10, 2022
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Research led by Peter Mac and published in Cancer Discovery has found a new combination therapy for acute myeloid leukemia (AML) that shows greater potency in a preclinical study than either drug used alone.
Jun 1, 2022
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Scientists from St. Jude Children's Research Hospital have shown that the innate immune sensor, ZBP1, and its associated inflammatory cell death pathway, PANoptosis, are major contributors to the negative effects of interferon ...
May 19, 2022
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Bacterial infections, such as dysentery caused by Shigella, are responsible for millions of deaths each year, but whether these bacteria are also able to interfere with the body's ability to fight the infection was previously ...
May 13, 2022
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[Northwestern Medicine investigators have discovered a novel signaling pathway activated by interferons, a group of immune system proteins, that suppresses the anti-tumor response of interferons in patients with a particular ...
Apr 19, 2022
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Researchers at the University of Michigan Rogel Cancer Center found that a cytokine, a category of protein that acts as messengers in the body, and a fatty acid can work together to trigger a type of cell death previously ...
Mar 4, 2022
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The world knows SARS-CoV-2 intimately now, but there are more than 200 virus species capable of infecting humans and causing disease. And they all want to do the same thing: Invade the host cells, hijack each cell's machinery ...
Jan 18, 2022
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184
Research led by scientists at the Jonsson Comprehensive Cancer Center (JCCC) at UCLA provides new insights into molecular "crosstalk" in pancreas cancer cells, identifying vulnerabilities that could provide a target for therapeutic ...
Jan 11, 2022
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Scientists have just slotted into place a big piece of the puzzle that explains how our blood cells mount their first line of defense against viruses. They hope this discovery will help them one day better control the response ...
Jan 10, 2022
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110
Fundamental differences in the immune response of adults and children can help to explain why children are much less likely to become seriously ill from SARS-CoV-2, according to new research from the Wellcome Sanger Institute, ...
Dec 22, 2021
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