When Vertex Pharmaceuticals announced last month that its investigational stem-cell-derived replacement therapy was, in conjunction with immunosuppressive therapy, helping the first patient in a Phase 1/2 clinical trial robustly ...
Nov 11, 2021
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Why do patients who receive antipsychotic medications to manage schizophrenia and bipolar disorder quickly gain weight and develop prediabetes and hyperinsulemia? The question remained a mystery for decades, but in a paper ...
Feb 16, 2021
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Scientists have broadened our understanding of how 'weak' cells bond with their more mature cellular counterparts to boost the body's production of insulin, improving our knowledge of the processes leading to type 2 diabetes—a ...
Jan 29, 2021
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Vanderbilt researchers have discovered a unique pathway that initiates islet β cell inflammation—a hallmark of type 2 diabetes—putting them a step closer to developing targeted therapeutics for the disease that affects ...
Jan 13, 2021
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A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery ...
Dec 4, 2020
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A team of researchers affiliated with multiple institutions in the U.S. has successfully tested the idea of transplanting pancreatic islet cells under the skin to treat diabetes in test mice and monkeys. In their paper published ...
Pancreatic islet transplants, which revive insulin production to treat type 1 diabetes, only last an average of three years.
Aug 31, 2020
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A protein that's common throughout the body plays a key role in regulating glucose levels, says new research conducted in the Cell Signal Unit at the Okinawa Institute of Science and Technology Graduate University (OIST) ...
Aug 28, 2020
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The multicellular, 3-D structure of human pancreatic islets—the areas of the pancreas containing hormone-producing or endocrine cells—has presented challenges to researchers as they study and manipulate these cells' function, ...
Jul 31, 2020
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Scientists at Sanford Burnham Prebys Medical Discovery Institute have mapped for the first time the vast network of proteins that interact with proinsulin, the protein the body normally processes into insulin. The study, ...
May 27, 2020
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