Blocking telomerase kills cancer cells but provokes resistance, progression
Inhibiting telomerase, an enzyme that rescues malignant cells from destruction by extending the protective caps on the ends of chromosomes, kills tumor cells but also triggers resistance pathways that allow cancer to survive ...
Cancer
Feb 21, 2012 |
5 / 5 (2) |
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Neurobiologists identify animal model for a deadly human metabolic disorder
In medical research, finding a reliable and cost-effective animal model can greatly enhance success in identifying disease mechanisms and genetic pathways, potentially cutting years off drug testing regimes and development ...
Neuroscience
Feb 13, 2012 |
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Surprising pathway implicated in stuttering
Researchers at Washington University School of Medicine in St. Louis have obtained new evidence that at least some persistent stuttering is caused by mutations in a gene governing not speech, but a metabolic pathway involved ...
Genetics
Nov 22, 2011 |
4.5 / 5 (2) |
2
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Tumor-specific pathway identified
A research team led by UT Southwestern Medical Center scientists has identified an atypical metabolic pathway unique to some tumors, possibly providing a future target for drugs that could reduce or halt the spread of cancer.
Cancer
Nov 22, 2011 |
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How cancer cells get by on a starvation diet
Cancer cells usually live in an environment with limited supplies of the nutrients they need to proliferate — most notably, oxygen and glucose. However, they are still able to divide uncontrollably, producing ...
Cancer
Nov 21, 2011 |
5 / 5 (2) |
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Vascular risk linked to long-term antiepileptic drug therapy
New research reveals that patients with epilepsy who were treated for extended periods with older generation antiepileptic drugs (AEDs) may be at increased risk for developing atherosclerosis, a common disorder known as hardening ...
Cardiology
Nov 15, 2011 |
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Study identifies genetic basis of human metabolic individuality
In what is so far the largest investigation of its kind, researchers uncovered a wide range of new insights about common diseases and how they are affected by differences between two persons' genes. The results from this ...
Genetics
Oct 26, 2011 |
3.3 / 5 (3) |
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Inflammation controlled differently in brain and other tissues, study finds
A team led by scientists from The Scripps Research Institute has identified a new metabolic pathway for controlling brain inflammation, suggesting strategies for treating it.
Medical research
Oct 20, 2011 |
4.9 / 5 (7) |
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Novel therapeutic target identified to decrease triglycerides and increase 'good' cholesterol
Researchers at NYU Langone Medical Center today announce findings published in the October 20 issue of Nature that show for the first time the inhibition of both microRNA-33a and microRNA-33b (miR-33a/b) with chemically modifi ...
Medical research
Oct 20, 2011 |
4 / 5 (1) |
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Premature babies at risk of ill health in later life, research suggests
Young adults who were born prematurely show multiple biological signs of risks to future health, research from Imperial College London has found. The scientists, reporting their findings tomorrow in the journal Pediatric Re ...
Health
Oct 18, 2011 |
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Dioxin-like chemical messenger makes brain tumors more aggressive
A research alliance of Heidelberg University Hospital and the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), jointly with colleagues of the Helmholtz Center for Environmental Research in Leipzig, ...
Cancer
Oct 06, 2011 |
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Large meta-analysis finds new genes for type 1 diabetes
The largest-ever analysis of genetic data related to type 1 diabetes has uncovered new genes associated with the common metabolic disease, which affects 200 million people worldwide. The findings add to knowledge of gene ...
Genetics
Sep 29, 2011 |
5 / 5 (1) |
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Diabetes and cancer: A shared biological basis
Contrary to what you might think, cancer and diabetes appear to have some biology in common. According to a report in the September 30th issue of the Cell Press journal, Cell, a pathway that initially drew attention for it ...
Medical research
Sep 29, 2011 |
4 / 5 (1) |
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Researchers discover a treatment against an aggressive childhood cancer
A study made by IDIBELL researchers shows that glucose metabolism inhibition with 2-deoxyglucose (2-DG) induces cell death in a type of childhood sarcoma: alveolar rhabdomyosarcoma. The results have been published in the ...
Cancer
Sep 14, 2011 |
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Metabolic state of brain cancer stem cells significantly different than the cancer cells they create
The metabolic state of glioma stem cells, which give rise to deadly glioblastomas, is significantly different from that of the brain cancer cells to which they give birth, a factor which helps those stem cells avoid treatment ...
Cancer
Sep 06, 2011 |
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