News tagged with microrna

Related topics: cancer , proceedings of the national academy of sciences , rna

New research provides insight into epilepsy

Experiments using mice have led to new research results showing that the amount of microRNA-128 has a great impact on the musculoskeletal system. If the level of microRNA-128 is increased, it leads to lower ...

Dec 20, 2013
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Synthetic RNAs designed to fight cancer

(Medical Xpress)—In search of better cancer treatments, researchers at Washington University School of Medicine in St. Louis have designed synthetic molecules that combine the advantages of two experimental ...

Dec 06, 2013
popularity 5 / 5 (2) | comments 0 | with audio podcast

MicroRNA-31 might predict lung-cancer spread

(Medical Xpress)—Determining whether a patient's lung cancer has spread to nearby lymph nodes is critical for identifying the most effective therapy, but it usually requires surgery. A new study suggests, however, that ...

Sep 24, 2013
popularity 5 / 5 (1) | comments 0 | with audio podcast

Gene decoding obeys road traffic rules

One of life's most basic processes—transcription of the genetic code—resembles road traffic, including traffic jams, accidents and a police force that controls the flow of vehicles. This surprising finding, reported recently ...

Jul 31, 2013
popularity 3.8 / 5 (4) | comments 0 | with audio podcast

Serum miR-21 putative biomarker for colorectal cancer

(HealthDay)—The oncogenic microRNA (miRNA) miR-21 is a potential biomarker for detection and prognosis of colorectal cancer (CRC), according to a study published in the June 19 issue of the Journal of the Na ...

Jun 20, 2013
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MicroRNA

In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (i.e. they are non-coding RNAs); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression. They were first described in 1993 by Lee and colleagues in the Victor Ambros lab , yet the term microRNA was only introduced in 2001 in a set of three articles in Science.

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