Acute myeloid leukemia (AML) is an aggressive blood cancer that is currently incurable in 70% of patients. In a bold effort, CSHL scientists are among those identifying and characterizing the molecular mechanisms responsible ...
Feb 11, 2013
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Behaving something like ravenous monsters, tumors need plentiful supplies of cellular building blocks such as amino acids and nucleotides in order to keep growing at a rapid pace and survive under harsh conditions. How such ...
Aug 23, 2012
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Researchers with UCLA's Jonsson Comprehensive Cancer Center have developed and used a high-throughput molecular screening approach that identifies and characterizes chemical compounds that can target the stem cells that are ...
Oct 11, 2011
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After attacking a tumor with a targeted therapy, the cancer might stagger but often comes back fighting—usually even harder to defeat. University of Saskatchewan (USask)-led research has revealed a promising strategy to ...
Mar 29, 2023
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Many cardiovascular diseases, such as atherosclerosis, or "hardening of the arteries," correlate to mitochondrial dysfunction and endothelial impairment in the tissues of the heart and blood vessels. Despite a significant ...
Jan 24, 2023
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Glioblastoma multiforme (GBM) is one of the most aggressive, fast-growing tumor types, and the most common cancer of the brain with a median overall survival of approximately 15 months. Despite recent advances in treatment ...
Aug 2, 2022
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New research has shown that the antidepressant sertraline inhibits the growth of cancer cells. It acts on a metabolic addiction that allows different types of cancer to grow. This is shown by a study on cell cultures and ...
Nov 17, 2020
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A novel agent that targets a mutated form of the KRAS gene—the most commonly altered oncogene in human cancers and one long considered "undruggable"—shrank tumors in most patients in a clinical trial with manageable side ...
Oct 25, 2020
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Researchers at The Wistar Institute and collaborators from the University of Notre Dame are developing anticancer compounds targeting a pathway of the endoplasmic reticulum (ER) stress response implicated in the development ...
Oct 13, 2020
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Researchers have discovered a new class of drug that has the potential to help cancer patients who no longer respond to existing therapies.
Apr 10, 2018
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