Oncology & Cancer

How 'trained immunity' mediates BCG therapy of bladder cancer

Bacillus Calmette-Guerin (BCG) is a vaccine widely used in low and middle-income countries to protect against childhood tuberculosis. Besides its specific anti-tuberculosis effects, BCG can also function as a general immune-booster, ...

Medical research

Serendipity leads to lifesaving discovery

McGill research team recently published new findings in the New England Journal of Medicine, pointing to a critical role for IRF8 in the development and function of monocytes and dendritic cells and in protecting against ...

Obstetrics & gynaecology

Study reveals genetic differences among fetal monocytes

A multidisciplinary team of Northwestern Medicine investigators has discovered striking differences in gene expression of monocytes—specialized immune cells—in the developing fetus, according to findings published in ...

Immunology

Gene editing expands to new types of immune cells

In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) ...

Oncology & Cancer

New clue to aggressive brain tumors

(Medical Xpress)—Scientists at Washington University School of Medicine in St. Louis have identified a biological marker that may help predict survival in people with deadly brain tumors. The researchers showed that when ...

Neuroscience

Regulating blood supply to limbs improves stroke recovery

Cutting off and then restoring blood supply to a limb following a stroke reduces tissue damage and swelling and improves functional recovery, according to a new study in mice published in JNeurosci. The simple, noninvasive ...

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