Maternal diabetes impairs methylation of imprinted gene in oocytes
For the first time, researchers have shown that poorly controlled maternal diabetes has an adverse effect on methylation of the maternal imprinting gene Peg3, contributing to impaired development in offspring.
Diabetes
Mar 20, 2013 |
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Secrets of a t-haplotype gene revealed: Decade-long hunt turns up key gene involved in early mammalian development
The t haplotype in mice—a block of linked genes occupying the proximal half of mouse chromosome 17—is one of the best-studied examples of a selfish genetic element. Through an elaborate sperm-poisoning ...
Genetics
Mar 08, 2013 |
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Genes for autism and schizophrenia only active in developing brains
Genes linked to autism and schizophrenia are only switched on during the early stages of brain development, according to a study in mice led by researchers at the University of Oxford.
Genetics
Feb 11, 2013 |
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One of the key circuits in regulating genes involved in producing blood stem cells is deciphered
Researchers from the group on stem cells and cancer at IMIM (Hospital del Mar Medical Research Institute) have deciphered one of the gene regulation circuits which would make it possible to generate hematopoietic blood cells, ...
Genetics
Jan 31, 2013 |
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New research refutes claim iPSCs are prone to immune response
(Medical Xpress)—Researchers in Japan have injected induced pluripotent stem cells (iPSCs) from mice back into genetically identical mice and report that doing so caused no immune reaction. This contradicts the results ...
Medical research
Jan 10, 2013 |
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Gene knockout stops immune cell development
(Medical Xpress)—Researchers at the Wellcome Trust Sanger Institute have identified the key gene in ensuring that our immune defences develop infection-fighting cells. No cells of the adaptive immune system ...
Immunology
Dec 11, 2012 |
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Inheritance of mitochondrial disease determined when mother is still an embryo
(Medical Xpress)—The risk of a child to inherit mitochondrial diseases - i. e. malfunction in what is usually referred to as the power plants of the cell - is largely decided when the future mother herself is still an embryo. ...
Genetics
Oct 08, 2012 |
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Research identifies protein that regulates key 'fate' decision in cortical progenitor cells
Researchers at Cold Spring Harbor Laboratory (CSHL) have solved an important piece of one of neuroscience's outstanding puzzles: how progenitor cells in the developing mammalian brain reproduce themselves while also giving ...
Neuroscience
Sep 21, 2012 |
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Study implicates marijuana use in pregnancy problems
New research indicates marijuana-like compounds called endocannabinoids alter genes and biological signals critical to the formation of a normal placenta during pregnancy and may contribute to pregnancy complications like ...
Medical research
Sep 12, 2012 |
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New model of muscular dystrophy provides insight into disease development
Muscular dystrophy is a complicated set of genetic diseases in which genetic mutations affect the various proteins that contribute to a complex that is required for a structural bridge between muscle cells and the extracellular ...
Medical research
Aug 27, 2012 |
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Artificial thymus tissue enables maturation of immune cells
The thymus plays a key role in the body's immune response. It is here where the T lymphocytes or T cells, a major type of immune defence cells, mature. Different types of T cells, designated to perform specific ...
Immunology
Mar 29, 2012 |
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Scientists discover primitive gut's role in left-right patterning
Scientists have found that the gut endoderm has a significant role in propagating the information that determines whether organs develop in the stereotypical left-right pattern. Their findings are published 6 March 2012 in ...
Medical research
Mar 06, 2012 |
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Artificial 'womb' unlocks secrets of early embryo development
(Medical Xpress) -- Pioneering work by a leading University of Nottingham scientist has helped reveal for the first time a vital process in the development of the early mammalian embryo.
Medical research
Mar 02, 2012 |
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Scientists identify crucial cell and signaling pathway in placental blood stem cell niche
(Medical Xpress) -- UCLA stem-cell researchers have identified a certain type of cell and a signaling pathway in the placental niche that play a key role in stopping blood stem cells from differentiating into mature blood ...
Medical research
Mar 01, 2012 |
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Scientists use an old theory to discover new targets in the fight against breast cancer
Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists at the Salk Institute for Biological Studies have ...
Cancer
Feb 07, 2012 |
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