In Leigh syndrome, infants are born apparently healthy only to develop movement and breathing disorders that worsen over time, often leading to death by the age of 3. The problem is that the mitochondria responsible for powering ...
Sep 6, 2011
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More powerful gene-sequencing tools have increasingly been uncovering disease secrets in DNA within the cell nucleus. Now a research team is expanding those rapid next-generation sequencing tests to analyze a separate source ...
Jan 29, 2013
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It seems impossible, right? We have been taught from the time we were young that babies are made when a sperm and an egg come together, and the DNA from these two cells combine to make a unique individual with half the DNA ...
Jun 15, 2018
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Almost 2,500 women of child-bearing age in the UK are at risk of transmitting mitochondrial disease to their children, according to the most recent estimates published today in the New England Journal of Medicine.
Jan 28, 2015
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Using advanced imaging technology, Mayo Clinic scientists have provided an unprecedented understanding of the BRCA1-BARD1 protein complex, which is often mutated in patients with breast or ovarian cancer. Their paper, published ...
Jul 28, 2021
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Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute discovered an important biological phenomenon in human cells that will help scientists and clinicians design safer treatments to prevent mitochondrial ...
May 19, 2016
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When the United Kingdom resoundingly approved mitochondrial replacement therapy in February, it became the first country to give people this new medical option. In parallel it gave the United States serious cause to reflect ...
Apr 10, 2015
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In a genome-wide analysis of 13 metastatic prostate cancers, scientists at the Johns Hopkins Kimmel Cancer Center found consistent epigenetic "signatures" across all metastatic tumors in each patient. The discovery of the ...
Jan 23, 2013
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A team at the CRCHUM—Université de Montréal's hospital research center—has discovered a new function for proteins responsible for DNA repair in the control of an inflammatory response in aging cells, also known as senescent ...
Aug 12, 2020
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Researchers at Sanford-Burnham Medical Research Institute have determined the complete three-dimensional structure of a protein called HNF-4α. HNF-4α controls gene expression in the liver and pancreas, switching genes on ...
Mar 13, 2013
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