News tagged with sodium channel
Investigating devastating childhood diseases just got easier
Induced pluripotent stem cells (iPScs) from the skin of patients with Dravet syndrome (DS) show Dravet-like functional impairment when they are converted into neurons, finds research in BioMed Central's open ...
Medical research
May 01, 2013 |
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Exploring the cause of sudden unexplained death in epilepsy
Dravet syndrome (DS) is a form of infantile-onset, treatment-resistant epilepsy that is caused by a mutation in the gene encoding a voltage-gated sodium channel, SCN1A. DS patients have a 30-fold increased risk of dying from ...
Medical research
Mar 25, 2013 |
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Researchers use iPSCs to define optimal treatment for managing life-threatening arrhythmias
Researchers used induced pluripotent stem cells (iPSCs) derived from a young patient with Long QT syndrome (LQTS), a congenital heart disorder, to determine a course of treatment that helped manage the patient's ...
Cardiology
Jan 11, 2013 |
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In a world of chronic pain, individual treatment possible, research shows
An investigation into the molecular causes of a debilitating condition known as "Man on Fire Syndrome" has led Yale researchers to develop a strategy that may lead to personalized pain therapy and predict which chronic pain ...
Medical research
Nov 13, 2012 |
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Novel therapy for improving airway hydration status in cystic fibrosis patients
Cystic fibrosis is one of the most common inherited single gene diseases, with an incidence of 1 out of 3,000 newborns in central Europe. An EU study developed a novel gene therapy approach for improving ...
Diseases, Conditions, Syndromes
Sep 20, 2012 |
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Novel blood test predicts sudden death risk patients who would benefit from ICDs
A novel blood test that predicts sudden death risk in heart failure patients is set to help physicians decide which patients would benefit from implantable cardioverter defibrillators (ICDs). The findings were presented at ...
Cardiology
Aug 27, 2012 |
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Low-dose sedative alleviates autistic-like behavior in mice with Dravet syndrome mutation
A low dose of the sedative clonazepam alleviated autistic-like behavior in mice with a mutation that causes Dravet syndrome in humans, University of Washington researchers have shown.
Diseases, Conditions, Syndromes
Aug 22, 2012 |
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Immune system uses heart channel to select powerful defenders
(Medical Xpress) -- When the body makes immune T cells, it relies on a molecular channel more commonly seen in nerves and heart muscles to ensure that the powerful T cells have the right mixture of aggressiveness ...
Immunology
Aug 16, 2012 |
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New proteins to clear the airways in cystic fibrosis and COPD
University of North Carolina scientists have uncovered a new strategy that may one day help people with cystic fibrosis and chronic obstructive pulmonary disorder better clear the thick and sticky mucus that clogs their lungs ...
Diseases, Conditions, Syndromes
Jul 13, 2012 |
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An 'off' switch for pain: Chemists build light-controlled neural inhibitor
Pain? Just turn it off! It may sound like science fiction, but researchers based in Munich, Berkeley and Bordeaux have now succeeded in inhibiting pain-sensitive neurons on demand, in the laboratory. The crucial element in ...
Medical research
Feb 22, 2012 |
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Researchers illuminate link between sodium, calcium and heartbeat
Using the Canadian Light Source synchrotron, researchers from the University of British Columbia have revealed, for the first time, one of the molecular mechanisms that regulates the beating of heart cells by controlling ...
Medical research
Feb 13, 2012 |
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Researcher develops model to foster new drug development to treat pain and epilepsy
Drawing on X-ray crystallography and experimental data, as well as a software suite for predicting and designing protein structures, a UC Davis School of Medicine researcher has developed an algorithm that predicts what has ...
Medical research
Dec 12, 2011 |
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Abnormal activation of a protein may explain deadly link between high salt intake and obesity
Dietary salt intake and obesity are two important risk factors in the development of high blood pressure. Each packs its own punch, but when combined, they deliver more damage to the heart and kidneys than the sum of their ...
Medical research
Sep 19, 2011 |
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Atomic structure discovered for a sodium channel that generates electrical signals in living cells
Scientists at the University of Washington (UW) in Seattle have determined the atomic architecture of a sodium channel. The achievement opens new possibilities for molecular medicine researchers around the world in designing ...
Medical research
Jul 13, 2011 |
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Neuroscientists' discovery could bring relief to epilepsy sufferers
Researchers at the University of California, Riverside have made a discovery in the lab that could help drug manufacturers develop new antiepileptic drugs and explore novel strategies for treating seizures associated with ...
Medical research
Jun 21, 2011 |
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