News tagged with target genes
Related topics: genes , gene expression , cancer cells , cells , transcription factors
Unraveling why children with Down syndrome have increased leukemia risk
Children with Down syndrome (DS) have an increased risk of developing leukemia, in particular acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic leukemia (ALL). Through their studies in a mouse model of DS, a ...
Genetics
Feb 22, 2012 |
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Role of known cancer gene in ovarian cancer investigated
The role of a known cancer-causing gene in the development of the most lethal type of ovarian cancer is being investigated by researchers from the Walter and Eliza Hall Institute after they were awarded a Cure Cancer Australia ...
Cancer
Feb 14, 2012 |
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Researchers increase understanding of gene's potentially protective role in Parkinson's
Treatments for Parkinson's disease, estimated to affect 1 million Americans, have yet to prove effective in slowing the progression of the debilitating disease.
Neuroscience
Feb 07, 2012 |
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Parkinson's disease: Study of live human neurons reveals the disease's genetic origins
Parkinson's disease researchers at the University at Buffalo have discovered how mutations in the parkin gene cause the disease, which afflicts at least 500,000 Americans and for which there is no cure.
Parkinson's & Movement disorders
Feb 07, 2012 |
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Three is the magic number: A chain reaction required to prevent tumor formation
Protein p53 is known for controlling the life and death of a cell and has a key role in cancer research. P53 is known to be inactive in 50 percent of cancer patients. If researchers succeed in re-establishing the presence ...
Cancer
Jan 20, 2012 |
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Unexpected discovery opens up new opportunities for targeting cancer
Scientists at the University of Leicester have opened up a whole new approach to the therapeutic intervention for a family of anti-cancer drug targets, thanks to a completely new and unexpected finding.
Cancer
Jan 10, 2012 |
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Researchers map potential genetic origins, pathways of lung cancer in nonsmokers
Researchers at the Translational Genomics Research Institute (TGen) have begun to identify mutations and cellular pathway changes that lead to lung cancer in never-smokers -- a first step in developing potential therapeutic ...
Cancer
Jan 09, 2012 |
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Antifolates show promise against NSCLC subtype
Patients with non-small cell lung cancer who have mutations in the KRAS gene should respond well to the antifolate class of drugs, according to results of a recent study conducted by Quintiles comparing human lung cancer ...
Cancer
Nov 14, 2011 |
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Signaling pathway linked to inflammatory breast cancer may drive disease metastasis
Amplification of anaplastic lymphoma kinase, which has been reported in other cancers such as non-small cell lung cancers, may be a primary driver of the rapid metastasis that patients with inflammatory breast cancer experience.
Inflammatory disorders
Nov 13, 2011 |
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Tamoxifen resistance -- and how to defeat it
In the last three decades, thousands of women with breast cancer have taken the drug tamoxifen, only to discover that the therapy doesn't work, either because their tumors do not respond to the treatment at all, or because ...
Cancer
Nov 13, 2011 |
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Gene therapy kills breast cancer stem cells, boosts chemotherapy
Gene therapy delivered directly to a particularly stubborn type of breast cancer cell causes the cells to self-destruct, lowers chance of recurrence and helps increase the effectiveness of some types of chemotherapy, researchers ...
Cancer
Sep 12, 2011 |
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Promising target in treating and preventing the progression of heart failure identified
Researchers at Mount Sinai School of Medicine have identified a new drug target that may treat and/or prevent heart failure. The team evaluated failing human and pig hearts and discovered that SUMO1, a so-called "chaperone" ...
Cardiology
Sep 07, 2011 |
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Small molecules shed light on cancer therapies
Patients suffering from an aggressive brain cancer will benefit from the results of a University of Illinois study that could advance the development of targeted gene therapies and improve prognosis.
Cancer
Aug 22, 2011 |
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Genetic analysis of amniotic fluid shows promise for monitoring fetal development
Researchers have demonstrated the feasibility of focused fetal gene expression analysis of target genes found in amniotic fluid using Standardized NanoArray PCR (SNAP) technology. This analysis could be used to monitor fetal ...
Genetics
Aug 08, 2011 |
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New mouse model for testing cancer drugs
Only one in twenty cancer drugs makes its way from the laboratory to become an approved pharmaceutical product. The majority of new agents are only shown to be unsuitable in the later phases of clinical development which ...
Cancer
Jul 19, 2011 |
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