News tagged with targeted therapy
Treating drug resistant cancer through targeted inhibition of sphingosine kinase
Scientists at Tulane University School of Medicine, led by Dr. James Antoon and Dr. Barbara Beckman, have characterized two drugs targeting sphingosine kinase (SK), an enzyme involved in cancer growth and metastasis. New ...
Cancer
Aug 09, 2012 |
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Scientists use worms to unearth cancer drug targets
Through novel experiments involving small nematode worms, scientists from Wyoming have discovered several genes that may be potential targets for drug development in the ongoing war against cancer. Specifically, researchers ...
Cancer
Aug 09, 2012 |
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New genetic target found for diuretic therapy
Researchers at the University of Cincinnati (UC) have identified a new genetic target for diuretic therapy in patients with fluid overload—like those with congestive heart failure, liver cirrhosis or kidney failure.
Genetics
Jul 30, 2012 |
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New therapeutic target for prostate cancer identified
A small, naturally occurring nucleic acid sequence, called a microRNA, known to regulate a number of different cancers, appears to alter the activity of the androgen receptor, which plays a critical role in ...
Cancer
Jul 17, 2012 |
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Transforming cancer treatment: Multidrug strategy emerges from new research
A Harvard researcher studying the evolution of drug resistance in cancer says that, in a few decades, “many, many cancers could be manageable.”
Cancer
Jul 11, 2012 |
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PI3K/mTOR pathway proteins tied to poor prognosis in breast cancer
Four proteins involved in translation, the final step of general protein production, are associated with poor prognosis in hormone-receptor-positive breast cancer when they are dysregulated, researchers reported at the AACR ...
Cancer
Apr 01, 2012 |
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Energy network within cells may be new target for cancer therapy
Mitochondria, tiny structures within each cell that regulate metabolism and energy use, may be a promising new target for cancer therapy, according to a new study. Manipulation of two biochemical signals that regulate the ...
Cancer
Feb 21, 2012 |
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Novel monoclonal antibody offers potential treatment for tumors resistant to VEGF therapy
Despite the widespread use of current antiangiogenic cancer therapies, many tumors escape this blockade, which is designed to shut down growth of new blood vessels that feed tumors and spread cancer cells. Now, a study reported ...
Cancer
Nov 13, 2011 |
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Tamoxifen resistance -- and how to defeat it
In the last three decades, thousands of women with breast cancer have taken the drug tamoxifen, only to discover that the therapy doesn't work, either because their tumors do not respond to the treatment at all, or because ...
Cancer
Nov 13, 2011 |
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Promising target in treating and preventing the progression of heart failure identified
Researchers at Mount Sinai School of Medicine have identified a new drug target that may treat and/or prevent heart failure. The team evaluated failing human and pig hearts and discovered that SUMO1, a so-called "chaperone" ...
Cardiology
Sep 07, 2011 |
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Researchers map pathway of infection for a common, potentially life-threatening respiratory virus
Researchers at the University of Toronto, The Hospital for Sick Children (SickKids), St. Paul's Hospital and the University of British Columbia have identified a new treatment target for a virus that causes severe lung infections ...
Medical research
Aug 15, 2011 |
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Scientists discover new pathway to potential therapies for advanced prostate cancer
UT Southwestern Medical Center researchers have narrowed the potential drug targets for advanced prostate cancer by demonstrating that late-stage tumors are driven by a different hormonal pathway than was thought previously.
Cancer
Jul 25, 2011 |
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Parkinson's disease patients may benefit from virtual-reality-based therapies
In people with Parkinson's Disease (PD), the inability to make quick movements limits basic functioning in daily life. Movement can be improved by various cueing techniques, such as providing visual or auditory stimuli when ...
Medical research
Jul 11, 2011 |
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Higher doses of radiation in fewer treatments proved safe, effective for low-risk prostate cancer
In a multicenter clinical trial, UT Southwestern Medical Center researchers have found that higher doses of stereotactic radiation therapy requiring fewer treatments are safe and effective for patients with low-to-intermediate-risk ...
Cancer
Jun 02, 2011 |
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