In a new paper published in Nature Communications, Mayo Clinic researchers and collaborators report the protein-coding gene SERPINA5 may worsen tau protein tangles, which are characteristic of Alzheimer's disease, and advance ...
Apr 19, 2021
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Researchers have used a genetic engineering strategy to dramatically reduce levels of tau—a key protein that accumulates and becomes tangled in the brain during the development of Alzheimer's disease—in an animal model ...
Mar 19, 2021
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Tau is a protein that helps stabilize the internal skeleton of nerve cells (neurons) in the brain. Groups of toxic tau protein, termed tau oligomers, drive disease progression and memory loss in Alzheimer's disease (AD). ...
Feb 22, 2021
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A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein, a hallmark of Alzheimer's ...
Dec 1, 2020
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Decades before the first symptoms of Alzheimer's appear, the brain's neurons start secreting tau proteins, one of the first changes known to occur in the course of the disease.
Nov 25, 2020
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Researchers from Tokyo Metropolitan University have discovered a new mechanism by which clumps of tau protein are created in the brain, killing brain cells and causing Alzheimer's disease. A specific mutation to an enzyme ...
Oct 26, 2020
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A new, rare genetic form of dementia has been discovered by a team of Penn Medicine researchers. This discovery also sheds light on a new pathway that leads to protein build up in the brain—which causes this newly discovered ...
Oct 2, 2020
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Researchers at the University of Alabama at Birmingham are on the track of a gene that might play a role in the development of Alzheimer's disease. The research team is studying a gene called BIN1, which was first linked ...
Sep 4, 2020
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Dozens of molecules may tangle up with rogue bundles of tau, a protein that normally gives nerve fibers structure, to cause brain cell damage that contributes to neurodegenerative diseases, a new study shows.
Jul 28, 2020
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Researchers at Karolinska Institutet have imaged tau protein in the brains of living patients with Alzheimer's disease. The amount and spread of tau proved a predictor of future memory loss. Brain imaging for measuring tau ...
Jul 3, 2020
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