The two U.S. FDA approved oligonucleotide-based drugs on the market both have a modified chemical backbone made of phosphorothioates. The therapeutic advantages of the phosphorothioate group and the new types of gene expression-regulation ...
Nov 13, 2014
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Breast cancer is the most frequent neoplasm among women, impacting 2.1 million women per year. It also has a high risk for intracranial spread. Researchers estimate that up to 30% of all patients with cancer will eventually ...
Sep 28, 2020
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A research team led by Junior Associate Professor Kazuo Takayama (CiRA, Kyoto University) and Professor Kei Sato (Institute of Medical Science, The University of Tokyo) experimentally infected human keratinocytes and human ...
Jun 20, 2023
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There's a major roadblock to creating personalized cancer care. Doctors need a way to target treatments to patients most likely to benefit and avoid treating those who will not. Tumor biomarker tests can help do this.
Aug 1, 2013
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While the mutated KRAS oncogene is associated with many cancers, it has not yet been successfully targeted by a therapeutic agent. Scientists are trying to find another way to target the gene by blocking signals from another ...
May 28, 2013
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The powerful anti-inflammatory compound interleukin-10 (IL-10) plays a crucial role in regenerative, scarless healing of fetal skin. Studies of IL-10 in postnatal skin wounds have demonstrated its promise as an anti-scarring ...
May 8, 2014
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Humans are exposed to various environmental or dietary molecules that can attenuate or even increase the effect of therapeutic drugs. Studies on the industrial chemical bisphenol A and the phytoestrogen genistein, for example, ...
Dec 1, 2020
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The European Union on Thursday pledged 144 million euros of fresh funding for research on rare diseases that currently affect some 30 million Europeans, the majority of them children.
Feb 28, 2013
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Although a large majority of head and neck cancers have a deregulation of the PI3K/AKT/mTOR pathway, data recently published in Cancer Research, a journal of the American Association for Cancer Research, indicated that deregulation ...
Jan 29, 2013
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The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2016) showed that tiny particles made of a biodegradable polymer (BNPs—biodegradable polymer nanoparticles) have the ...
Jun 9, 2016
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