Arthritis & Rheumatism

How mitochondrial damage ignites the 'auto-inflammatory fire'

Mitochondria are self-contained organelles (they possess their own mini-chromosome and DNA) residing within cells and are charged with the job of generating the chemical energy needed to fuel functions essential to life and ...

Medical research

Severe flu risk as immune cells swap with age

Lung infections with the influenza virus or a coronavirus more frequently result in severe disease progression in older people. This is due to an excessive inflammatory reaction that causes damage to the lung tissue. The ...

Diseases, Conditions, Syndromes

Why do some people get sicker from COVID than others?

COVID-19 vaccines have saved at least a million lives in the United States alone, but for many people, a lingering fear remains: If—or when—they get hit by the coronavirus, just how bad will it be? Will they breeze through ...

Inflammatory disorders

Scientists switch on tissue repair in inflammatory bowel disease

A method that instructs immune system cells to help repair damaged tissues in the intestine has been developed by researchers at KU Leuven and Seoul National University. This opens the way for more effective treatment of ...

Immunology

New insights into the control of inflammation

Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. ...

Immunology

New research may explain severe virus attacks on the lungs

In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers at Karolinska Institutet in Sweden describe how immune cells called macrophages develop in the lungs and which ...

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