News tagged with transcription factors

Related topics: genes , cells , gene expression , stem cells , dna sequences

Some immune cells defend only one organ

(Medical Xpress)—Scientists have uncovered a new way the immune system may fight cancers and viral infections. The finding could aid efforts to use immune cells to treat illness.

Apr 17, 2014
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Switching brain development on and off

(Medical Xpress)—The possibility of nerve cell regeneration is a step closer after neuroscientists identified the genetic signals that play a crucial role in normal development - driving stem cells to produce ...

Jan 30, 2014
popularity 4.4 / 5 (8) | comments 0 | with audio podcast

Key protein accelerates diabetes in two ways

The same protein tells beta cells in the pancreas to stop making insulin and then to self-destruct as diabetes worsens, according to a University of Alabama at Birmingham (UAB) study published online today ...

Aug 26, 2013
popularity 5 / 5 (2) | comments 0 | with audio podcast

Transcription factor

In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the transfer (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme which performs the transcription of genetic information from DNA to RNA) to specific genes.

A defining feature of transcription factors is that they contain one or more DNA binding domains (DBDs) which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA binding domains, and therefore are not classified as transcription factors.

This text uses material from Wikipedia licensed under CC BY-SA