News tagged with transcription factors
Researchers at UT Southwestern Medical Center have identified a specific gene that regulates the heart's ability to regenerate after injuries.
Genetics Apr 17, 2013 | 4.7 / 5 (3) | 0 |
The powerful master regulatory transcription factor called Bcl6 is key to the survival of a majority of aggressive lymphomas, which arise from the B-cells of the immune system. The protein has long been considered too complex ...
Immunology Mar 03, 2013 | 5 / 5 (6) | 0 |
How does one's experience of an event get translated into a memory that can be accessed months, even years later? A team led by University of Pennsylvania scientists has come closer to answering that question, identifying ...
Medical research Sep 10, 2012 | 5 / 5 (6) | 3 |
UCLA stem cell researchers have found for the first time a surprising and unexpected plasticity in the embryonic endothelium, the place where blood stem cells are made in early development.
Medical research Aug 02, 2012 | not rated yet | 0 |
For more than 20 years, doctors have been using cells from blood that remains in the placenta and umbilical cord after childbirth to treat a variety of illnesses, from cancer and immune disorders to blood ...
Medical research Jul 16, 2012 | 5 / 5 (5) | 0 |
In a paper published in the July 11 online issue of Science Translational Medicine, researchers at the University of California, San Diego School of Medicine have identified two key regulatory proteins critic ...
Neuroscience Jul 11, 2012 | 4.8 / 5 (4) | 0 |
Breast cancer is not a single disease, but a collection of diseases with dozens of different mutations that crop up with varying frequency across different breast cancer subtypes. Deeper exploration of the genetic changes ...
Cancer Jun 20, 2012 | not rated yet | 0 |
Arrhythmia is a potentially life-threatening problem with the rate or rhythm of the heartbeat, causing it to go too fast, too slow or to beat irregularly. Arrhythmia affects millions of people worldwide.
Genetics Dec 27, 2011 | 5 / 5 (3) | 0 |
A major international study has identified a novel gene mutation that appears to increase the risk of both inherited and sporadic cases of malignant melanoma, the most deadly form of skin cancer. The identified mutation occurs ...
Cancer Nov 13, 2011 | not rated yet | 0 |
Cells develop and thrive by turning genes on and off as needed in a precise pattern, a process known as regulated gene transcription. In a paper published in the Nov. 9 issue of the Journal of Neuroscience, researchers at the ...
Neuroscience Nov 10, 2011 | not rated yet | 0 |
Cells, like ordinary households, produce "garbage" debris and dysfunctional elements that need disposal. When the mechanism for taking out this garbage fails, rare genetic diseases called lysosomal storage disorders ...
Genetics May 26, 2011 | 3 / 5 (1) | 0 |
(Medical Xpress)—Researchers at the University of Illinois have identified biomarkers that can be used to determine ovarian cancer survival and recurrence, and have shown how these biomarkers interact with ...
Cancer Apr 30, 2013 | not rated yet | 1 |
University of North Carolina researchers have discovered that disrupting a gene that acts as a regulatory switch to turn on other genes can keep blood vessels from forming and developing properly.
Medical research Apr 29, 2013 | 5 / 5 (1) | 0 |
For a long time, scientists have dreamed of converting undesirable white fat cells into brown fat cells and thus simply have excess pounds melt away. Researchers at the University of Bonn have now gotten ...
Medical research Apr 23, 2013 | 5 / 5 (2) | 0 |
Understanding the molecular control of placenta formation, the organ which enables fetal growth, is critical in diagnosing and treating related pregnancy complications. A group of scientists at the Chinese Academy of Sciences, ...
Medical research Apr 16, 2013 | not rated yet | 0 |
In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the transfer (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme which performs the transcription of genetic information from DNA to RNA) to specific genes.
A defining feature of transcription factors is that they contain one or more DNA binding domains (DBDs) which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA binding domains, and therefore are not classified as transcription factors.
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