News tagged with tumor antigens
Two-pronged approach to immune activation could lead to vaccines that effectively shut down tumor expansion
Tumor cells often express proteins that set them apart from their healthy neighbors. These very same proteins can also help the immune system to recognize and destroy the cancer. Several research groups and ...
Cancer
Apr 26, 2013 |
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Engineered T cells kill tumors but spare normal tissue in an animal model
The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs. Tumor antigens, unique proteins on the surface of a tumor, are potential targets for a normal ...
Cancer
Apr 07, 2013 |
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Reprogrammed immune cells might give doctors an edge in rallying the body's defenses against tumor growth
Genetic abnormalities accrued by tumor cells lead to inappropriate production of proteins at the wrong time or place, or even the synthesis of unusual hybrid proteins not found in normal cells. Such abnormalities ...
Cancer
Mar 01, 2013 |
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Infusion of stem cells and specially generated T-cells from same donor improves leukemia survival
In a significant advance for harnessing the immune system to treat leukemias, researchers at Fred Hutchinson Cancer Research Center for the first time have successfully infused large numbers of donor T-cells specific for ...
Cancer
Feb 27, 2013 |
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Can we all just get along? Immunological memory learns tolerance
(Medical Xpress)—Immunology researchers at the University of Connecticut Health Center are learning more about memory T cells, which are cells that fight infection from a previously encountered antigen.
Immunology
Jan 15, 2013 |
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New immune therapy treats brain tumors in mice
Using an artificial protein that stimulates the body's natural immune system to fight cancer, a research team at Duke Medicine has engineered a lethal weapon that kills brain tumors in mice while sparing ...
Immunology
Dec 17, 2012 |
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Prostate cancer now detectable by imaging-guided biopsy
Ground-breaking research by a UCLA team of physicians and engineers demonstrates that prostate cancer can be diagnosed using image-guided targeted biopsy.
Cancer
Dec 10, 2012 |
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Leukemia patients remain in remission more than two years after engineered T cell therapy
Nine of twelve leukemia patients who received infusions of their own T cells after the cells had been genetically engineered to attack the patients' tumors responded to the therapy, which was pioneered by scientists in the ...
Cancer
Dec 10, 2012 |
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Mouse model exposes a new type of T cell to target melanoma
Cancers arise in the body all the time. Most are nipped in the bud by the immune response, not least by its T cells, which detect telltale molecular markers—or antigens—on cancer cells and destroy them before they grow ...
Cancer
Oct 24, 2012 |
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UC Irvine opens clinical trial of novel treatment for brain cancer
UC Irvine doctors are enrolling patients with the deadly brain tumor glioblastoma multiforme in a clinical trial of a vaccine that may prevent the cancer's return or spread after surgery.
Cancer
Oct 10, 2012 |
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Regulatory immune cell diversity tempers autoimmunity in rheumatoid arthritis
Untangling the root cause of rheumatoid arthritis has been a difficult task for immunologists, as decades of research has pointed to multiple culprits in our immune system, with contradictory lines of evidence. Now, researchers ...
Arthritis & Rheumatism
May 08, 2012 |
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Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
While active monitoring of serum prostate specific antigen (PSA) levels in men over 50 has greatly improved early detection of prostate cancer, prediction of clinical outcomes after diagnosis remains a major challenge. Researchers ...
Cancer
May 07, 2012 |
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Pox vaccines extend survival for patients with melanoma, ovarian cancer
An immunotherapy regimen incorporating poxviruses and targeting a particular tumor antigen, NY-ESO-1, has shown promise in treating two types of cancers. Kunle Odunsi, MD, PhD, Chair of the Department of Gynecologic Oncology ...
Cancer
Mar 26, 2012 |
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New universal platform for cancer immunotherapy developed
(Medical Xpress) -- Researchers from the Perelman School of Medicine at the University of Pennsylvania report this month in Cancer Research a universal approach to personalized cancer therapy based on T c ...
Cancer
Mar 05, 2012 |
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Researchers find sarcoma tumor immune response with combination therapy
A team of 18 researchers at Moffitt Cancer Center in Tampa, Fla., have found that treating high-risk, soft tissue sarcoma patients with a combination of implanted dendritic cells (immune system cells) and fractionated external ...
Cancer
Mar 01, 2012 |
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