Simponi approved for ulcerative colitis
(HealthDay)—Simponi (golimumab) injection has been approved by the U.S. Food and Drug Administration to treat adults with moderate-to-severe ulcerative colitis.
Medications
May 15, 2013 |
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Frequently used biologic agents might cause acute liver injury
A commonly used class of biologic response modifying drugs can cause acute liver injury with elevated liver enzymes, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journa ...
Diseases, Conditions, Syndromes
Apr 29, 2013 |
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Use of biologic therapies for inflammatory diseases does not appear to increase risk of shingles
Patients with rheumatoid arthritis (RA) who initiated use of anti-tumor necrosis factor therapies were not at a higher risk of developing herpes zoster (shingles), compared with patients who initiated nonbiologic ...
Inflammatory disorders
Apr 19, 2013 |
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Immune response linked to key enzyme
(Medical Xpress)—A previously unknown function of a family of enzymes familiar to biologists may contribute to scientists' understanding of signaling molecules involved in the body's immune response and ...
Immunology
Apr 12, 2013 |
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Cell-destroyer that fights and promotes TB reveals what's behind its split identity
Tumor necrosis factor—normally an infection-fighting substance produced by the body—can actually heighten susceptibility to tuberculosis if its levels are too high. University of Washington TB researchers ...
Diseases, Conditions, Syndromes
Apr 11, 2013 |
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Researchers probe the enigma of healing element that is also the enemy
The same factor in our immune system that is instrumental in enabling us to fight off severe and dangerous inflammatory ailments is also a player in doing the opposite at a later stage, causing the suppression of our immune ...
Immunology
Apr 03, 2013 |
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Use of certain therapies for inflammatory diseases does not appear to increase risk of shingles
Although patients with rheumatoid arthritis (RA) have a disproportionately higher incidence of herpes zoster (shingles), an analysis that included nearly 60,000 patients with RA and other inflammatory diseases found that ...
Inflammatory disorders
Mar 05, 2013 |
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Brain activity linked to TNF inhibitor response in RA
(HealthDay)—Patients with rheumatoid arthritis who respond to tumor necrosis factor inhibitors (TNFi) show changes in activity in pain-related areas of the brain before clinical signs of improvement are ...
Arthritis & Rheumatism
Feb 12, 2013 |
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Medroxyprogesterone acetate linked to immune suppression
(HealthDay)—Use of the injectable contraceptive depot medroxyprogesterone acetate (MPA), common in areas such as sub-Saharan Africa with high HIV-1 prevalence, is associated with suppression of the immune ...
Immunology
Feb 01, 2013 |
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Researchers identify new target for rheumatoid arthritis
Researchers at Hospital for Special Surgery have identified a potential new target for drugs to treat patients with rheumatoid arthritis (RA), a protein known as IRHOM2. The finding could provide an effective ...
Arthritis & Rheumatism
Jan 25, 2013 |
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Monitoring of immune function in critically ill kids with influenza reveals severe immune suppression in non-survivors
(Medical Xpress)—Investigators from 15 children's medical centers, including Nationwide Children's Hospital, observed and evaluated critically ill children with influenza to evaluate the relationships between levels of ...
Immunology
Jan 17, 2013 |
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Etanercept seems beneficial in partial spinal cord injury
(HealthDay)—Treatment of rabbits with a partial spinal cord injury (SCI) with the intramuscularly-administered tumor necrosis factor-α (TNF-α) inhibitor etanercept is associated with improved clinical ...
Diseases, Conditions, Syndromes
Jan 11, 2013 |
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Cancer therapy: Nanokey opens tumors to attack
There are plenty of effective anticancer agents around. The problem is that, very often, they cannot gain access to all the cells in solid tumors. A new gene delivery vehicle may provide a way of making tracks to the heart ...
Cancer
Nov 14, 2012 |
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Study finds potential new drug therapy for Crohn's disease
Ustekinumab, an antibody proven to treat the skin condition psoriasis, has now shown positive results in decreasing the debilitating effects of Crohn's Disease, according to researchers at the University of California San ...
Diseases, Conditions, Syndromes
Oct 17, 2012 |
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Lexatumumab tolerated for pediatric solid tumors
(HealthDay)—Lexatumumab, an agonistic, full human monoclonal antibody against tumor necrosis factor-related apoptosis-inducing ligand receptor 2, is well tolerated and may lessen certain clinical symptoms ...
Cancer
Oct 16, 2012 |
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