COUP-TFII sparks prostate cancer progression
Prostate cancer presents a dilemma for patients and the physicians who treat them. Which cancers are essentially indolent and present no risk and which are life threatening? Which can be watched and which need aggressive ...
Cancer
Nov 28, 2012 |
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Researchers link new molecular culprit to breast cancer progression
(Phys.org)—Johns Hopkins researchers have uncovered a protein "partner" commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery, published November ...
Cancer
Nov 25, 2012 |
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Can the addition of radiolabeled treatments improve outcomes in advanced metastatic disease?
Radiolabeled agents are powerful tools for targeting and killing cancer cells and may help improve outcomes and lengthen survival times of patients with advanced disease that has spread beyond the initial ...
Cancer
Nov 13, 2012 |
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Inhibition of enzyme NOX4 prevents liver fibrosis
Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have led a study published in PLoS One showing that the inhibition of a family member of NADPH oxidase enzyme, NOX4, plays an important role in liver fibros ...
Diseases, Conditions, Syndromes
Nov 05, 2012 |
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Combination treatment may improve survival of breast cancer patients with brain metastases
Adding an angiogenesis inhibitor to treatment with a HER2-inhibiting drug could improve outcomes for patients with HER2-positive breast cancer who develop brain metastases. In their report published online in PNAS Plus, ...
Cancer
Nov 01, 2012 |
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Endotrophin links obesity to breast cancer progression
Fat cells (adipocytes) surround breast tumors and contribute to tumor growth by expressing factors that aid oncogenesis. Col6 is a protein that is highly expressed in adipocytes and its expression is further increased in ...
Cancer
Oct 08, 2012 |
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New function of a protein involved in colon cancer is identified
Researchers from IMIM, Hospital del Mar Medical Research Institute, have succeeded in determining the function of a new variant of enzyme IKKalpha (IKKα) to activate some of the genes taking part in the tumor progressions ...
Cancer
Oct 04, 2012 |
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Taming physical forces that block cancer treatment
A Massachusetts General Hospital research team has identified factors that contribute to solid stress within tumors, suggesting possible ways to alleviate it, and has developed a simple way to measure such pressures.
Cancer
Sep 20, 2012 |
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Do you want to know another role of ribonucleotide reductase M2?
Ribonucleotide reductase (RR) is a target metabolic enzymes for cancer therapy. Few studies have described the correlation between RRM2 and the development of colorectal cancer. And the possible mechanism by which RRM2 mediates ...
Cancer
Sep 18, 2012 |
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Lack of oxygen in cancer cells leads to growth and metastasis
(Medical Xpress)—It seems as if a tumor deprived of oxygen would shrink. However, numerous studies have shown that tumor hypoxia, in which portions of the tumor have significantly low oxygen concentrations, ...
Cancer
Sep 13, 2012 |
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Bonanza of genomic sequence data gives researchers valuable new insights into a poorly understood cancer
Stomach cancer doesn't get the same publicity as lung or breast cancer, but it is a health threat to be taken very seriously. "Gastric cancer is the second leading cause of worldwide cancer mortality, with ...
Genetics
Sep 12, 2012 |
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Researchers reveal a chemo-resistant cancer stem cell as cancer's 'Achilles' heel'
Scientists at Mount Sinai School of Medicine have discovered a subpopulation of cells that display cancer stem cell properties and resistance to chemotherapy, and participate in tumor progression. This breakthrough could ...
Cancer
Sep 10, 2012 |
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Researchers find acidic pH microenvironments in tumors aid tumor cell survival
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and Wayne State University have discovered that tumor cell survival relies on adaptation to acidic conditions in the tumor microenvironment. ...
Cancer
Sep 06, 2012 |
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Taking breaks from prostate cancer hormone therapy seems safe: study
(HealthDay)—Stop-and-start hormone-deprivation therapy for localized prostate cancer doesn't shorten overall survival compared to continuous treatments, and yields fewer side effects such as impotence and ...
Cancer
Sep 05, 2012 |
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Team finds biological indicator of aggressive, recurrent forms of prostate cancer
(Medical Xpress)—In a study to decipher clues about how prostate cancer cells grow and become more aggressive, Johns Hopkins urologists have found that reduction of a specific protein is correlated with the aggressiveness ...
Cancer
Aug 27, 2012 |
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